Background: Not all breast cancer patients benefit from neoadjuvant or adjuvant therapy,
resulting in considerable undertreatment or overtreatment. New insights into the role of …

Type I interferons (IFNs) are pro-inflammatory cytokines that are rapidly induced in different
cell types during viral infections. The consequences of type I IFN signalling include direct …

Lymphoid and myeloid cells are abundant in the tumor microenvironment, can be quantified
by immunohistochemistry and shape the disease course of human solid tumors. Yet, there is …

The observation that a subset of cancer patients show evidence for spontaneous CD8+ T
cell priming against tumor-associated antigens has generated renewed interest in the innate …

Although robust and highly effective anti-viral T cells contribute to the clearance of many
acute infections, viral persistence is associated with the development of functionally inferior …

One of the most appreciated consequences of immunosenescence is an impaired response
to vaccines with advanced age. While most studies report impaired antibody responses in …

The immune infiltration of tumors is closely related to clinical outcomes. The composition of
tumor-infiltrating immune cells (TIICs) can serve as biomarkers for predicting response to …

Natural killer cells (NK) are highly enriched in the human liver, where they can regulate
immunity and immunopathology. We probed them for a liver-resident subset, distinct from …

The genetic factors associated with susceptibility or resistance to viral infections are likely to
involve a sophisticated array of immune response. These genetic elements may modulate …

While type I interferons (IFNs) are universally acknowledged for their antiviral and
immunostimulatory functions, there is increasing appreciation of the detrimental effects of …