CAR T‐Cell Therapy for Multiple Myeloma: A Clinical Practice‐Oriented Review

NL Sadek, BA Costa, K Nath… - Clinical Pharmacology …, 2023 - Wiley Online Library
The emergence of chimeric antigen receptor (CAR) T‐cell therapy has revolutionized the
treatment of hematologic malignancies, including multiple myeloma (MM). Two BCMA …

[HTML][HTML] Metronomic chemotherapy in hematology: Lessons from preclinical and clinical studies to build a solid rationale for future schedules

M Banchi, MC Cox, G Bocci - Cancer Letters, 2024 - Elsevier
Metronomic chemotherapy (mCHEMO), based on frequent, regular administration of low, but
pharmacologically active drug doses, optimizes antitumor efficacy by targeting multiple …

Dual-targeted NAMPT inhibitors as a progressive strategy for cancer therapy

F Ozgencil, HB Gunindi, G Eren - Bioorganic Chemistry, 2024 - Elsevier
In mammals, nicotinamide phosphoribosyltransferase (NAMPT) is a crucial enzyme in the
nicotinamide adenine dinucleotide (NAD+) synthesis pathway catalyzing the condensation …

Role of Immune Cells and Immunotherapy in Multiple Myeloma

V Radhakrishnan, U Golla, AK Kudva - Life, 2024 - mdpi.com
The clinical signs of multiple myeloma, a plasma cell (PC) dyscrasia, include bone loss,
renal damage, and paraproteinemia. It can be defined as the uncontrolled growth of …

Novel chemotherapy combination of carfilzomib with dexamethasone, cyclophosphamide, etoposide and cisplatin (K-DCEP) for the treatment of relapsed/refractory …

CB Wagner, K Julian, B Bryan, MN Steinbach… - Leukemia & …, 2024 - Taylor & Francis
Advances in the treatment of multiple myeloma (MM) have led to improvements in patient
survival. however, the disease course is characterized by periods of disease control …

Comparable Efficacy of Oral Bendamustine versus Intravenous Administration in Treating Hematologic Malignancies

MJ Cracchiolo, L Davis, AP Matiatos, DW Davini… - 2024 - researchsquare.com
Purpose: The purpose of this study was to analyze potential differences in antitumor efficacy
and pharmacokinetics between intravenous (IV) bendamustine (BEN) and a novel orally …

Research Progress on Anti-tumor Mechanism of Artesunate Combined Drugs

M Shi, X Yang - Academic Journal of Science and Technology, 2024 - drpress.org
Artesunate (ART) is a semi-synthetic artemisinin derivative of hemiterpene lactones, which is
widely used in clinical antimalarial therapy. In recent years, studies have shown that …