Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions

C Qin, S Yang, YH Chu, H Zhang, XW Pang… - Signal transduction and …, 2022 - nature.com
Ischemic stroke is caused primarily by an interruption in cerebral blood flow, which induces
severe neural injuries, and is one of the leading causes of death and disability worldwide …

Oxidative stress and antioxidants in neurodegenerative disorders

EO Olufunmilayo, MB Gerke-Duncan, RMD Holsinger - Antioxidants, 2023 - mdpi.com
Neurodegenerative disorders constitute a substantial proportion of neurological diseases
with significant public health importance. The pathophysiology of neurodegenerative …

Ferroptosis: mechanisms, biology and role in disease

X Jiang, BR Stockwell, M Conrad - Nature reviews Molecular cell …, 2021 - nature.com
The research field of ferroptosis has seen exponential growth over the past few years, since
the term was coined in 2012. This unique modality of cell death, driven by iron-dependent …

Ferroptosis: mechanisms and links with diseases

H Yan, T Zou, Q Tuo, S Xu, H Li, AA Belaidi… - Signal transduction and …, 2021 - nature.com
Ferroptosis is an iron-dependent cell death, which is different from apoptosis, necrosis,
autophagy, and other forms of cell death. The process of ferroptotic cell death is defined by …

System Xc /GSH/GPX4 axis: An important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy

FJ Li, HZ Long, ZW Zhou, HY Luo, SG Xu… - Frontiers in …, 2022 - frontiersin.org
The activation of ferroptosis is a new effective way to treat drug-resistant solid tumors.
Ferroptosis is an iron-mediated form of cell death caused by the accumulation of lipid …

The chemistry and biology of ferroptosis

BR Stockwell, X Jiang - Cell chemical biology, 2020 - cell.com
Ferroptosis is a recently described form of cell death driven by iron-dependent lipid
peroxidation. This type of cell death was first observed in response to treatment of tumor …

Cell death pathways in ischemic stroke and targeted pharmacotherapy

A Datta, D Sarmah, L Mounica, H Kaur… - Translational stroke …, 2020 - Springer
Ischemic stroke is one of the significant causes of morbidity and mortality, affecting millions
of people across the globe. Cell injury in the infarct region is an inevitable consequence of …

Molecular mechanisms of glutamate toxicity in Parkinson's disease

J Wang, F Wang, D Mai, S Qu - Frontiers in neuroscience, 2020 - frontiersin.org
Parkinson's disease (PD) is a common neurodegenerative disease, the pathological
features of which include the presence of Lewy bodies and the neurodegeneration of …

The role of mitochondrial ROS in the aging brain

R Stefanatos, A Sanz - FEBS letters, 2018 - Wiley Online Library
The brain is the most complex human organ, consuming more energy than any other tissue
in proportion to its size. It relies heavily on mitochondria to produce energy and is made up …

Heavy metal mixture exposure and effects in developing nations: an update

BO Anyanwu, AN Ezejiofor, ZN Igweze, OE Orisakwe - Toxics, 2018 - mdpi.com
The drive for development and modernization has come at great cost. Various human
activities in developed and developing countries, particularly in sub-Saharan Africa (SSA) …