PharmVar GeneFocus: CYP2D6
C Nofziger, AJ Turner, K Sangkuhl… - Clinical …, 2020 - Wiley Online Library
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly
polymorphic human CYP2D6 gene locus. CYP2D6 genetic variation impacts the metabolism …
polymorphic human CYP2D6 gene locus. CYP2D6 genetic variation impacts the metabolism …
Complexities of CYP2D6 gene analysis and interpretation
A Gaedigk - International review of psychiatry, 2013 - Taylor & Francis
Abstract Cytochrome P450 2D6 (CYP2D6) plays an important role in the metabolism and
bioactivation of about 25% of clinically used drugs including many antidepressants …
bioactivation of about 25% of clinically used drugs including many antidepressants …
Therapeutics data commons: Machine learning datasets and tasks for drug discovery and development
Therapeutics machine learning is an emerging field with incredible opportunities for
innovatiaon and impact. However, advancement in this field requires formulation of …
innovatiaon and impact. However, advancement in this field requires formulation of …
Beyond generative models: superfast traversal, optimization, novelty, exploration and discovery (STONED) algorithm for molecules using SELFIES
Inverse design allows the generation of molecules with desirable physical quantities using
property optimization. Deep generative models have recently been applied to tackle inverse …
property optimization. Deep generative models have recently been applied to tackle inverse …
Interethnic variability of CYP2D6 alleles and of predicted and measured metabolic phenotypes across world populations
A LLerena, MEG Naranjo… - Expert opinion on …, 2014 - Taylor & Francis
Introduction: The frequency of CYP2D6 alleles, related to either a lack of or increased
enzymatic activity, which may lead to poor metabolism (PM) or ultrarapid metabolism (UM) …
enzymatic activity, which may lead to poor metabolism (PM) or ultrarapid metabolism (UM) …
Determinants of approved acetylcholinesterase inhibitor response outcomes in Alzheimer's disease: relevance for precision medicine in neurodegenerative diseases
Acetylcholinesterase inhibitors (ChEI) are the global standard of care for the symptomatic
treatment of Alzheimer's disease (AD) and show significant positive effects in …
treatment of Alzheimer's disease (AD) and show significant positive effects in …
Drug metabolism in preclinical drug development: a survey of the discovery process, toxicology, and computational tools
Background: While establishing efficacy in translational models and humans through
clinically-relevant endpoints for disease is of great interest, assessing the potential toxicity of …
clinically-relevant endpoints for disease is of great interest, assessing the potential toxicity of …
[PDF][PDF] Proteome‐wide analyses of human hepatocytes during differentiation and dedifferentiation
C Rowe, DT Gerrard, R Jenkins, A Berry, K Durkin… - …, 2013 - Wiley Online Library
Failure to predict hepatotoxic drugs in preclinical testing makes it imperative to develop
better liver models with a stable phenotype in culture. Stem cell‐derived models offer …
better liver models with a stable phenotype in culture. Stem cell‐derived models offer …
[HTML][HTML] DeamiDATE 1.0: Site-specific deamidation as a tool to assess authenticity of members of ancient proteomes
Contamination is a potential problem in the study of ancient proteins, either from prior
handling of the sample, laboratory consumables, or cross-sample carryover from mass …
handling of the sample, laboratory consumables, or cross-sample carryover from mass …
Atomoxetine: a review of its pharmacokinetics and pharmacogenomics relative to drug disposition
Atomoxetine is a selective norepinephrine (NE) reuptake inhibitor approved for the treatment
of attention-deficit/hyperactivity disorder (ADHD) in children (≥ 6 years of age), adolescents …
of attention-deficit/hyperactivity disorder (ADHD) in children (≥ 6 years of age), adolescents …