Purpose Metformin is associated with reduced breast cancer risk in observational studies in
patients with diabetes, but clinical evidence for antitumor activity is unclear. The change in Ki …

Digital pathology and the adoption of image analysis have grown rapidly in the last few
years. This is largely due to the implementation of whole slide scanning, advances in …

When the nucleolus disassembles during open mitosis, many nucleolar proteins and RNAs
associate with chromosomes, establishing a perichromosomal compartment coating the …

Lipophilic statins purportedly exert anti-tumoral effects on breast cancer by decreasing
proliferation and increasing apoptosis. HMG-CoA reductase (HMGCR), the rate-limiting …

Metformin may exert anti-cancer effects through indirect (insulin-mediated) or direct (insulin-
independent) mechanisms. We report results of a neoadjuvant “window of opportunity” study …

Classification of lung neuroendocrine (NE) tumors is a step-wise process with four tumor
categories being identified by morphology, namely typical carcinoid (TC), atypical carcinoid …

El cáncer de mama es la neoplasia más común en mujeres a nivel mundial, al igual que en
nuestro país. Sin embargo, en México, existen diferencias que son importantes de identificar …

Purpose To evaluate the relative effectiveness of letrozole compared with tamoxifen for
patients with invasive ductal or lobular carcinoma. Patients and Methods Patients diagnosed …

The higher incidence of breast cancer in developed countries has been tempered by
reductions in mortality, largely attributable to mammographic screening programmes and …

Adjuvant chemotherapy decisions in breast cancer are increasingly based on the
pathologist's assessment of tumor proliferation. The Swiss Working Group of Gyneco-and …