This paper introduces a new construct, the 'pivotal mental state', which is defined as a hyper-
plastic state aiding rapid and deep learning that can mediate psychological transformation …

Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients
with refractory epilepsy, with an estimated 35% lifetime risk in this patient population. There …

Lung ventilation fluctuates widely with behavior but arterial PCO 2 remains stable. Under
normal conditions, the chemoreflexes contribute to PaCO 2 stability by producing small …

Breathing movements in mammals are driven by rhythmic neural activity generated within
spatially and functionally organized brainstem neural circuits comprising the respiratory …

Respiratory depression limits the use of opioid analgesia. Although well described clinically,
the specific mechanisms of opioid action on respiratory control centres in the brain have …

Recent experiments in vivo and in vitro have advanced our understanding of the sites and
mechanisms involved in mammalian respiratory rhythm generation. Here we evaluate and …

Sudden unexpected death in epilepsy (SUDEP) is increasingly recognized as a common
and devastating problem. Because impaired breathing is thought to play a critical role in …

Mammalian central pattern generators (CPGs) producing rhythmic movements exhibit
extremely robust and flexible behavior. Network architectures that enable these features are …

Central chemoreception traditionally refers to a change in ventilation attributable to changes
in CO 2/H+ detected within the brain. Interest in central chemoreception has grown …

A long-standing theory posits that central chemoreception, the CNS mechanism for CO2
detection and regulation of breathing, involves neurons located at the ventral surface of the …