Loss-of-function mutations in the genes encoding either neurokinin B (NKB) or its receptor,
NK3 (NK3R), result in hypogonadotropic hypogonadism, characterized by an absence of …

Many mammalian species use chemosignals to coordinate reproduction by altering the
physiology and behavior of both sexes. Chemosignals prime reproductive physiology so that …

This review considers three aspects of recent work on the role of KNDy neurons in GnRH
pulse generation in ruminants. First, work on basic mechanisms of pulse generation …

Reproduction is a critically important event in every animals' life and in all vertebrates is
controlled by the brain via the hypothalamic-pituitary-gonadal (HPG) axis. In many species …

The reproductive neuropeptide gonadotropin-releasing hormone (GnRH) has two modes of
secretion. Besides the surge mode, which induces ovulation in females, the pulse mode of …

The recent description of infertility in humans with loss-of-function mutations in genes for
neurokinin B (NKB) or its receptor (NK3R) has focused attention on the importance of this …

Neurons synthesizing neurokinin B (NKB) and kisspeptin (KP) in the hypothalamic arcuate
nucleus represent important upstream regulators of pulsatile gonadotropin-releasing …

The introduction of a novel male stimulates the hypothalamic-pituitary-gonadal axis of
female sheep during seasonal anestrus, leading to the resumption of follicle maturation and …

Sociosexual stimuli have a profound effect on the physiology of all species. Sheep and
goats provide an ideal model to study the impact of sociosexual stimuli on the hypothalamic …

The aim of this study was to determine if exogenous administration of glutamate and (or)
testosterone to male rams during the season of reproductive arrest is able to re-activate …