Tumor organoid models in precision medicine and investigating cancer-stromal interactions
Tumor development and progression require chemical and mechanical cues derived from
cellular and non-cellular components in the tumor microenvironment, including the …
cellular and non-cellular components in the tumor microenvironment, including the …
Inflammation and metabolism in cancer cell—mitochondria key player
Cancer metabolism is an essential aspect of tumorigenesis, as cancer cells have increased
energy requirements in comparison to normal cells. Thus, an enhanced metabolism is …
energy requirements in comparison to normal cells. Thus, an enhanced metabolism is …
[HTML][HTML] Brown adipose tissue-derived exosomes mitigate the metabolic syndrome in high fat diet mice
X Zhou, Z Li, M Qi, P Zhao, Y Duan, G Yang, L Yuan - Theranostics, 2020 - ncbi.nlm.nih.gov
The ever-increasing incidence of obesity and related disorders impose serious challenges
on public health worldwide. Brown adipose tissue (BAT) has strong capacity for promoting …
on public health worldwide. Brown adipose tissue (BAT) has strong capacity for promoting …
Compression-induced dedifferentiation of adipocytes promotes tumor progression
Dysregulated physical stresses are generated during tumorigenesis that affect the
surrounding compliant tissues including adipocytes. However, the effect of physical …
surrounding compliant tissues including adipocytes. However, the effect of physical …
Adipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery
Obesity is a strong risk factor for cancer progression, posing obesity-related cancer as one of
the leading causes of death. Nevertheless, the molecular mechanisms that endow cancer …
the leading causes of death. Nevertheless, the molecular mechanisms that endow cancer …
Hepatocellular and extrahepatic cancer risk in people with non-alcoholic fatty liver disease
JA Thomas, BJ Kendall, HB El-Serag… - The Lancet …, 2024 - thelancet.com
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease
worldwide. Much of the recognised health-care burden occurs in the minority of people with …
worldwide. Much of the recognised health-care burden occurs in the minority of people with …
MicroRNAs and other non-coding RNAs in adipose tissue and obesity: emerging roles as biomarkers and therapeutic targets
S Lorente-Cebrián, P González-Muniesa… - Clinical …, 2019 - portlandpress.com
Obesity is a metabolic condition usually accompanied by insulin resistance (IR), type 2
diabetes (T2D), and dyslipidaemia, which is characterised by excessive fat accumulation …
diabetes (T2D), and dyslipidaemia, which is characterised by excessive fat accumulation …
Obesity and cancer metastasis: molecular and translational perspectives
Simple Summary A major challenge in treating cancer is when the cancer spreads from its
original site to other parts of the body, a process also known as metastasis. In order to …
original site to other parts of the body, a process also known as metastasis. In order to …
Modifying the tumour microenvironment and reverting tumour cells: New strategies for treating malignant tumours
YQ Cheng, SB Wang, JH Liu, L Jin, Y Liu… - Cell …, 2020 - Wiley Online Library
The tumour microenvironment (TME) plays a pivotal role in tumour fate determination. The
TME acts together with the genetic material of tumour cells to determine their initiation …
TME acts together with the genetic material of tumour cells to determine their initiation …
Morning chronotype and digestive tract cancers: Mendelian randomization study
Morning chronotype has been associated with a reduced risk of prostate and breast cancer.
However, few studies have examined whether chronotype is associated with digestive tract …
However, few studies have examined whether chronotype is associated with digestive tract …