[HTML][HTML] PLK1, a potential target for cancer therapy
Z Liu, Q Sun, X Wang - Translational oncology, 2017 - Elsevier
Abstract Polo-like kinase 1 (PLK1) plays an important role in the initiation, maintenance, and
completion of mitosis. Dysfunction of PLK1 may promote cancerous transformation and drive …
completion of mitosis. Dysfunction of PLK1 may promote cancerous transformation and drive …
Polo-like kinase 1 inhibitors in human cancer therapy: development and therapeutic potential
Polo-like kinase 1 (PLK1) plays an important role in a variety of cellular functions, including
the regulation of mitosis, DNA replication, autophagy, and the epithelial–mesenchymal …
the regulation of mitosis, DNA replication, autophagy, and the epithelial–mesenchymal …
[HTML][HTML] The global phosphorylation landscape of SARS-CoV-2 infection
M Bouhaddou, D Memon, B Meyer, KM White… - Cell, 2020 - cell.com
The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed …
respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed …
[HTML][HTML] Present and future perspective on PLK1 inhibition in cancer treatment
M Chiappa, S Petrella, G Damia, M Broggini… - Frontiers in …, 2022 - frontiersin.org
Polo-like kinase 1 (PLK1) is the principle member of the well conserved serine/threonine
kinase family. PLK1 has a key role in the progression of mitosis and recent evidence …
kinase family. PLK1 has a key role in the progression of mitosis and recent evidence …
Playing polo during mitosis: PLK1 takes the lead
Abstract Polo-like kinase 1 (PLK1), the prototypical member of the polo-like family of
serine/threonine kinases, is a pivotal regulator of mitosis and cytokinesis in eukaryotes …
serine/threonine kinases, is a pivotal regulator of mitosis and cytokinesis in eukaryotes …
Recent advances in site-specific lipid nanoparticles for mRNA delivery
The success of mRNA vaccines during the COVID-19 pandemic has greatly accelerated the
development of mRNA therapy. mRNA is a negatively charged nucleic acid that serves as a …
development of mRNA therapy. mRNA is a negatively charged nucleic acid that serves as a …
[HTML][HTML] Molecular targets of genistein and its related flavonoids to exert anticancer effects
Increased health awareness among the public has highlighted the health benefits of dietary
supplements including flavonoids. As flavonoids target several critical factors to exert a …
supplements including flavonoids. As flavonoids target several critical factors to exert a …
[HTML][HTML] Mitotic disassembly of nuclear pore complexes involves CDK1-and PLK1-mediated phosphorylation of key interconnecting nucleoporins
MI Linder, M Köhler, P Boersema, M Weberruss… - Developmental cell, 2017 - cell.com
During interphase, the nuclear envelope (NE) serves as a selective barrier between cytosol
and nucleoplasm. When vertebrate cells enter mitosis, the NE is dismantled in the process of …
and nucleoplasm. When vertebrate cells enter mitosis, the NE is dismantled in the process of …
[HTML][HTML] A new wave of innovations within the DNA damage response
Q Li, W Qian, Y Zhang, L Hu, S Chen… - Signal Transduction and …, 2023 - nature.com
Genome instability has been identified as one of the enabling hallmarks in cancer. DNA
damage response (DDR) network is responsible for maintenance of genome integrity in …
damage response (DDR) network is responsible for maintenance of genome integrity in …
[HTML][HTML] Channel nucleoporins recruit PLK-1 to nuclear pore complexes to direct nuclear envelope breakdown in C. elegans
L Martino, S Morchoisne-Bolhy, DK Cheerambathur… - Developmental cell, 2017 - cell.com
In animal cells, nuclear envelope breakdown (NEBD) is required for proper chromosome
segregation. Whereas mitotic kinases have been implicated in NEBD, how they coordinate …
segregation. Whereas mitotic kinases have been implicated in NEBD, how they coordinate …