Background: To promote model-informed precision dosing (MIPD) for vancomycin (VCM),
we developed statements for therapeutic drug monitoring (TDM). Methods: Ten clinical …

Antimicrobial pharmacology and its effect on prescribing is quite complex. Selecting an
antibiotic that will optimally treat an infection while minimizing adverse effects and the …

Importance The benefits of antimicrobial prophylaxis are limited to the first 24 hours
postoperatively. Little is known about the harms associated with continuing antimicrobial …

Purpose Although dozens of studies have associated vancomycin+ piperacillin–tazobactam
with increased acute kidney injury (AKI) risk, it is unclear whether the association represents …

Enterococcus faecalis, Enterococcus faecium and Staphylococcus aureus are both common
commensals and major opportunistic human pathogens. In recent decades, these bacteria …

Background This study analyzed the relationship between vancomycin area under the
concentration-time curve (AUC) and acute kidney injury (AKI) reported across recent studies …

Medications are a common cause of AKI, especially for patients admitted to hospital wards
and the intensive care unit. Although drug-related kidney injury occurs through different …

Vancomycin is the most frequently used antibiotic, accounting for up to 35% of hospitalized
patients with infection, because of its optimal bactericidal effectiveness and relatively low …

The accelerated appearance of drug-resistant bacteria poses an ever-growing threat to
modern medicine's capacity to fight infectious diseases. Gram-positive species such as …

Abstract Treatment of polymicrobial infections requires combination therapy with drugs that
have different antimicrobial spectra and possibly work in synergy. However, the different …