A long-term objective of network medicine is to replace our current, mainly phenotype-based
disease definitions by subtypes of health conditions corresponding to distinct …

In recent decades, the development of new drugs has become increasingly expensive and
inefficient, and the molecular mechanisms of most pharmaceuticals remain poorly …

In the 1950s and 1960s, in molecular biology, information technology was mainly applied to
the molecular evolution of proteins and DNA, and later expanded to multiple fields such as …

Vascular smooth muscle cell (VSMC) proliferation is a hallmark of neointimal hyperplasia
(NIH) in atherosclerosis and restenosis post-balloon angioplasty and stent insertion …

Molecular signatures have been excessively reported for diagnosis of many cancers during
the last 20 years. However, false-positive signatures are always found using statistical …

Classical approaches have been used for solving biological systems since the Newton time.
Most of the earlier effort has reduced a system to the simplest levels for the study. Such an …

Unsupervised patient stratification based on omics data is traditionally approached by
clustering methods which may be inefficient for datasets with multiple patterns overlapping …