Current studies on molecular mechanisms of insulin resistance

J Pei, B Wang, D Wang - Journal of Diabetes Research, 2022 - Wiley Online Library
Diabetes is a metabolic disease that raises the risk of microvascular and neurological
disorders. Insensitivity to insulin is a characteristic of type II diabetes, which accounts for 85 …

[HTML][HTML] Coronary heart disease in type 2 diabetes mellitus: genetic factors and their mechanisms, gene-gene, and gene-environment interactions in the asian …

KA Zarkasi, NA Abdul Murad, N Ahmad… - International Journal of …, 2022 - mdpi.com
Asians are more susceptible to type 2 diabetes mellitus (T2D) and its coronary heart disease
(CHD) complications than the Western populations, possibly due to genetic factors, higher …

[HTML][HTML] Transforming growth factor-β signaling pathway-associated genes SMAD2 and TGFBR2 are implicated in metabolic syndrome in a Taiwanese population

E Lin, PH Kuo, YL Liu, AC Yang, SJ Tsai - Scientific Reports, 2017 - nature.com
The transforming growth factor-β (TGF-β) signaling pathway and its relevant genes have
been correlated with an increased risk of developing various hallmarks of metabolic …

[HTML][HTML] Association and interaction of APOA5, BUD13, CETP, LIPA and health-related behavior with metabolic syndrome in a Taiwanese population

E Lin, PH Kuo, YL Liu, AC Yang, CF Kao, SJ Tsai - Scientific reports, 2016 - nature.com
Increased risk of developing metabolic syndrome (MetS) has been associated with the
APOA5, APOC1, BRAP, BUD13, CETP, LIPA, LPL, PLCG1, and ZPR1 genes. In this …

Targeting ENPP1 for cancer immunotherapy: Killing two birds with one stone

R Huang, Q Ning, J Zhao, X Zhao, L Zeng, Y Yi… - Biochemical …, 2023 - Elsevier
Cancer immunotherapy, particularly with immune checkpoint inhibitors, has revolutionized
the paradigm of cancer treatment. Nevertheless, the efficacy of cancer immunotherapy …

[HTML][HTML] Combination of G72 Genetic Variation and G72 Protein Level to Detect Schizophrenia: Machine Learning Approaches

E Lin, CH Lin, YL Lai, CH Huang, YJ Huang… - Frontiers in …, 2018 - frontiersin.org
The D-amino acid oxidase activator (DAOA, also known as G72) gene is a strong
schizophrenia susceptibility gene. Higher G72 protein levels have been implicated in …

[HTML][HTML] Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population

E Lin, SJ Tsai, PH Kuo, YL Liu, AC Yang, CF Kao - Oncotarget, 2017 - ncbi.nlm.nih.gov
Genome-wide association studies and meta-analyses implicated that increased risk of
developing Alzheimers diseases (AD) has been associated with the ABCA7, APOE, BIN1 …

[HTML][HTML] Detection of susceptibility loci on APOA5 and COLEC12 associated with metabolic syndrome using a genome-wide association study in a Taiwanese …

E Lin, PH Kuo, YL Liu, AC Yang, SJ Tsai - Oncotarget, 2017 - ncbi.nlm.nih.gov
Background Although the association of single nucleotide polymorphisms (SNPs) with
metabolic syndrome (MetS) has been reported in various populations in several genome …

[HTML][HTML] Effects of circadian clock genes and health-related behavior on metabolic syndrome in a Taiwanese population: Evidence from association and interaction …

E Lin, PH Kuo, YL Liu, AC Yang, CF Kao, SJ Tsai - PloS one, 2017 - journals.plos.org
Increased risk of developing metabolic syndrome (MetS) has been associated with the
circadian clock genes. In this study, we assessed whether 29 circadian clock-related genes …

Genetics and epigenetics purpose in nonalcoholic fatty liver disease

AE Botello-Manilla, NC Chávez-Tapia… - Expert Review of …, 2020 - Taylor & Francis
Introduction nonalcoholic fatty liver disease (NAFLD) comprises a broad spectrum of
diseases, which can progress from benign steatosis to nonalcoholic steatohepatitis, liver …