Systemic inflammation is a marker of poor prognosis preoperatively present in around 20%-
40% of colorectal cancer patients. The hallmarks of systemic inflammation include an …

Abstract Savla, Jainy J., Benjamin D. Levine, and Hesham A. Sadek. The effect of hypoxia
on cardiovascular disease: Friend or foe? High Alt Med Biol. 19: 124–130, 2018.—Over 140 …

Neonatal-streptozotocin (n-STZ)-induced diabetes mimics most of the clinicopathological
symptoms of type 2 diabetes mellitus (T2DM) peripheral neuropathy. Berberine, a plant …

Hypoxia is a condition during which the body or specific tissues are deprived of oxygen. This
phenomenon can occur in response to exposure to hypoxic environmental conditions such …

Physiologically based kinetic (PBK) models facilitate chemical risk assessment by predicting
in vivo exposure while reducing the need for animal testing. PBK models for mammals have …

More than 140 million people live and works (in a chronic or intermittent form) above 2500 m
worldwide and 35 million live in the Andean Mountains. Furthermore, in Chile, it is estimated …

Background: Living at high altitude or with chronic hypoxia implies functional and
morphological changes in the right ventricle and pulmonary vasculature with a 10 …

Adipose tissue metabolism and circulation play an important role in human health. It is well-
known that adipose tissue mass is increased in response to excess caloric intake leading to …

In some organisms and cells, oxygen availability influences oxygen consumption. In this
review, we examine this phenomenon of hypoxic hypometabolism (HH), discussing its …

Hyperlipidemia is a serious disorders affecting the metabolism of fats in the human body,
and it is usually associated with some serious cardiovascular complications increasing the …