Environmental pollution is one of the most serious challenges to health in the modern world.
Pollutants alter immune responses and can provoke immunotoxicity. In this Review, we …

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular
disease. We report the largest genetic association study of blood pressure traits (systolic …

Background Lower respiratory infections are a leading cause of morbidity and mortality
around the world. The Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study …

Background A growing body of research identifies the harmful effects that adverse childhood
experiences (ACEs; occurring during childhood or adolescence; eg, child maltreatment or …

52 Monitor tobacco use and prevention policies 64 Protect people from tobacco smoke 70
Offer help to quit tobacco use 76 Warn about the dangers of tobacco 76 Health warning …

Background Although the rising pandemic of obesity has received major attention in many
countries, the effects of this attention on trends and the disease burden of obesity remain …

Background Chronic obstructive pulmonary disease (COPD) and asthma are common
diseases with a heterogeneous distribution worldwide. Here, we present methods and …

Hypertension affects 30% of adults and is the leading risk factor for heart attack and stroke.
Traditionally, hypertension has been regarded as a disorder of two systems that are involved …

Background Exposure to ambient air pollution increases morbidity and mortality, and is a
leading contributor to global disease burden. We explored spatial and temporal trends in …

Given evident multiple threats to food systems and supplies, food security, human health
and welfare, the living and physical world and the biosphere, the years 2016–2025 are now …