Glioblastoma multiforme (GBM): An overview of current therapies and mechanisms of resistance

W Wu, JL Klockow, M Zhang, F Lafortune… - Pharmacological …, 2021 - Elsevier
Glioblastoma multiforme (GBM) is a WHO grade IV glioma and the most common malignant,
primary brain tumor with a 5-year survival of 7.2%. Its highly infiltrative nature, genetic …

[HTML][HTML] Redox dysregulation as a driver for DNA damage and its relationship to neurodegenerative diseases

S Shadfar, S Parakh, MS Jamali, JD Atkin - Translational …, 2023 - Springer
Redox homeostasis refers to the balance between the production of reactive oxygen species
(ROS) as well as reactive nitrogen species (RNS), and their elimination by antioxidants. It is …

[HTML][HTML] Targeting drug chemo-resistance in cancer using natural products

WH Talib, AR Alsayed, M Barakat, MI Abu-Taha… - Biomedicines, 2021 - mdpi.com
Cancer is one of the leading causes of death globally. The development of drug resistance
is the main contributor to cancer-related mortality. Cancer cells exploit multiple mechanisms …

Curcumin–cisplatin chemotherapy: A novel strategy in promoting chemotherapy efficacy and reducing side effects

Y Hussain, L Islam, H Khan, R Filosa… - Phytotherapy …, 2021 - Wiley Online Library
The efficacy of chemotherapy in cancer therapy is limited due to resistance, treatment
selectivity, and severe adverse effects. Immunotherapy, chemotherapy, targeted therapy …

[HTML][HTML] Radiogenomic classification for MGMT promoter methylation status using multi-omics fused feature space for least invasive diagnosis through mpMRI scans

SA Qureshi, L Hussain, U Ibrar, E Alabdulkreem… - Scientific reports, 2023 - nature.com
Accurate radiogenomic classification of brain tumors is important to improve the standard of
diagnosis, prognosis, and treatment planning for patients with glioblastoma. In this study, we …

[HTML][HTML] Molecular mechanisms of drug resistance in glioblastoma

MA Dymova, EV Kuligina, VA Richter - International journal of molecular …, 2021 - mdpi.com
Glioblastoma multiforme (GBM) is the most common and fatal primary brain tumor, is highly
resistant to conventional radiation and chemotherapy, and is not amenable to effective …

[HTML][HTML] Exosomal circWDR62 promotes temozolomide resistance and malignant progression through regulation of the miR-370-3p/MGMT axis in glioma

X Geng, Y Zhang, X Lin, Z Zeng, J Hu, L Hao, J Xu… - Cell death & …, 2022 - nature.com
Exosome-mediated delivery of circular RNAs (circRNAs) is implicated in cancer progression.
However, the role of exosomal circRNAs in the chemotherapy resistance of tumours remains …

[HTML][HTML] The role of hypoxia in glioblastoma radiotherapy resistance

AL Chédeville, PA Madureira - Cancers, 2021 - mdpi.com
Simple Summary Glioblastoma (GB) is the deadliest type of primary brain tumor. Following
diagnosis the patient´ s median survival is only 16 months. There are currently around 450 …

Exploring ncRNA-mediated regulation of EGFR signalling in glioblastoma: From mechanisms to therapeutics

R Thapa, M Afzal, A Goyal, G Gupta, AA Bhat… - Life sciences, 2024 - Elsevier
Glioblastoma (GBM) is the most prevalent and deadly primary brain tumor type, with a
discouragingly low survival rate and few effective treatments. An important function of the …

[HTML][HTML] Molecular targeted therapy: a new avenue in glioblastoma treatment

O El Atat, R Naser, M Abdelkhalek… - Oncology …, 2022 - spandidos-publications.com
Glioblastoma, also referred to as glioblastoma multiforme (GBM), is grade IV astrocytoma
characterized by being fast-growing and the most aggressive brain tumor. In adults, it is the …