Glioblastoma multiforme (GBM): An overview of current therapies and mechanisms of resistance
Glioblastoma multiforme (GBM) is a WHO grade IV glioma and the most common malignant,
primary brain tumor with a 5-year survival of 7.2%. Its highly infiltrative nature, genetic …
primary brain tumor with a 5-year survival of 7.2%. Its highly infiltrative nature, genetic …
[HTML][HTML] Redox dysregulation as a driver for DNA damage and its relationship to neurodegenerative diseases
Redox homeostasis refers to the balance between the production of reactive oxygen species
(ROS) as well as reactive nitrogen species (RNS), and their elimination by antioxidants. It is …
(ROS) as well as reactive nitrogen species (RNS), and their elimination by antioxidants. It is …
[HTML][HTML] Targeting drug chemo-resistance in cancer using natural products
Cancer is one of the leading causes of death globally. The development of drug resistance
is the main contributor to cancer-related mortality. Cancer cells exploit multiple mechanisms …
is the main contributor to cancer-related mortality. Cancer cells exploit multiple mechanisms …
Curcumin–cisplatin chemotherapy: A novel strategy in promoting chemotherapy efficacy and reducing side effects
The efficacy of chemotherapy in cancer therapy is limited due to resistance, treatment
selectivity, and severe adverse effects. Immunotherapy, chemotherapy, targeted therapy …
selectivity, and severe adverse effects. Immunotherapy, chemotherapy, targeted therapy …
[HTML][HTML] Radiogenomic classification for MGMT promoter methylation status using multi-omics fused feature space for least invasive diagnosis through mpMRI scans
Accurate radiogenomic classification of brain tumors is important to improve the standard of
diagnosis, prognosis, and treatment planning for patients with glioblastoma. In this study, we …
diagnosis, prognosis, and treatment planning for patients with glioblastoma. In this study, we …
[HTML][HTML] Molecular mechanisms of drug resistance in glioblastoma
MA Dymova, EV Kuligina, VA Richter - International journal of molecular …, 2021 - mdpi.com
Glioblastoma multiforme (GBM) is the most common and fatal primary brain tumor, is highly
resistant to conventional radiation and chemotherapy, and is not amenable to effective …
resistant to conventional radiation and chemotherapy, and is not amenable to effective …
[HTML][HTML] Exosomal circWDR62 promotes temozolomide resistance and malignant progression through regulation of the miR-370-3p/MGMT axis in glioma
X Geng, Y Zhang, X Lin, Z Zeng, J Hu, L Hao, J Xu… - Cell death & …, 2022 - nature.com
Exosome-mediated delivery of circular RNAs (circRNAs) is implicated in cancer progression.
However, the role of exosomal circRNAs in the chemotherapy resistance of tumours remains …
However, the role of exosomal circRNAs in the chemotherapy resistance of tumours remains …
[HTML][HTML] The role of hypoxia in glioblastoma radiotherapy resistance
AL Chédeville, PA Madureira - Cancers, 2021 - mdpi.com
Simple Summary Glioblastoma (GB) is the deadliest type of primary brain tumor. Following
diagnosis the patient´ s median survival is only 16 months. There are currently around 450 …
diagnosis the patient´ s median survival is only 16 months. There are currently around 450 …
Exploring ncRNA-mediated regulation of EGFR signalling in glioblastoma: From mechanisms to therapeutics
Glioblastoma (GBM) is the most prevalent and deadly primary brain tumor type, with a
discouragingly low survival rate and few effective treatments. An important function of the …
discouragingly low survival rate and few effective treatments. An important function of the …
[HTML][HTML] Molecular targeted therapy: a new avenue in glioblastoma treatment
O El Atat, R Naser, M Abdelkhalek… - Oncology …, 2022 - spandidos-publications.com
Glioblastoma, also referred to as glioblastoma multiforme (GBM), is grade IV astrocytoma
characterized by being fast-growing and the most aggressive brain tumor. In adults, it is the …
characterized by being fast-growing and the most aggressive brain tumor. In adults, it is the …