The cellular functions of the microtubule (MT) cytoskeleton range from relatively simple to
amazingly complex. Assembled from tubulin, a heterodimeric protein with α-and β-tubulin …

Trypanosomes are characterised by the possession of a single flagellum and a subpellicular
microtubule cytoskeleton. The flagellum is more than an organelle for motility; its position …

Polyglutamylation of tubulin has been implicated in several functions of microtubules, but the
identification of the responsible enzyme (s) has been challenging. We found that the …

The application of single molecules as templates for nanodevices is a promising direction for
nanotechnology. We used a pair of suspended DNA molecules as templates for …

Background Ichthyophthirius multifiliis, commonly known as Ich, is a highly pathogenic
ciliate responsible for'white spot', a disease causing significant economic losses to the …

Basal bodies organize the nine doublet microtubules found in cilia. Cilia are required for a
variety of cellular functions, including motility and sensing stimuli. Understanding this …

* Abbreviations used in this paper: BB, basal body; cs, cold sensitive; CVP, contractile
vacuole pore; KF, kinetodesmal fiber; Mac, macronucleus; Mic, micronucleus; MT …

Tubulin undergoes glutamylation, a conserved posttranslational modification of poorly
understood function. We show here that in the ciliate Tetrahymena, most of the microtubule …

To improve the utility of increasingly large numbers of available unannotated and initially
poorly annotated genomic sequences for proteome analysis, we demonstrate that effective …

Two types of polymeric post-translational modifications of α/β-tubulin, glycylation and
glutamylation, occur widely in cilia and flagella. Their respective cellular functions are poorly …