Advancements in redox-sensitive micelles as nanotheranostics: a new horizon in cancer management

A Sikder, G Vambhurkar, E Amulya… - Journal of Controlled …, 2022 - Elsevier
Abstract World Health Organisation (WHO) delineated cancer as one of the foremost
reasons for mortality with 10 million deaths in the year 2020. Early diagnosis and effective …

Nose-to-brain delivery of rotigotine redispersible nanosuspension: In vitro and in vivo characterization

P Saha, H Kathuria, MM Pandey - Journal of Drug Delivery Science and …, 2023 - Elsevier
Rotigotine (RTG) is an anti-Parkinson's drug approved by the USFDA to treat motor and non-
motor symptoms of both early and advanced stages of the disease. However, issues like …

[HTML][HTML] Diosmin nanocrystal gel alleviates imiquimod-induced psoriasis in rats via modulating TLR7, 8/NF-κB/micro RNA-31, AKT/mTOR/P70S6K milieu, and Tregs …

Y Shahine, SAA El-Aal, AM Reda, E Sheta… - …, 2023 - Springer
Diosmin is a flavonoid with promising anti-inflammatory and antioxidant properties.
However, it has difficult physicochemical characteristics since its solubility demands a pH …

Green-step assembly of the supramolecular amphiphile constructed by sodium carboxymethyl cellulose and calixarene for facile loading of hydrophobic food bioactive …

R Kashapov, N Kashapova, Y Razuvayeva… - Food Chemistry, 2023 - Elsevier
The use of biologically active compounds is often limited due to their poor aqueous
solubility, which generally reduces their bioavailability and useful efficacy. In this regard, a …

Comparative Evaluation of Particle Size Reduction, Salt Formation, and Amorphous Formulation on the Biopharmaceutical Performance of a Weak Base Drug …

W Zhang, W Jia, BW Weitz, F Ma, Y Chen… - Molecular …, 2023 - ACS Publications
Various approaches have been developed to enhance the solubility or dissolution rate for
the delivery of poorly water-soluble molecules. In this work, guided by an in silico solubility …

Formulation and characterization of olmesartan medoxomil as a nanoparticle

RA Muhesen, NA Rajab - Research Journal of Pharmacy and …, 2023 - indianjournals.com
Aim The main object of this research work was the development and evaluation of
olmesartan medoxomil nanoparticle for the solubility and bioavailability improvement. It is …

Influence of surfactant-based polymer as micellar carrier on dissolution properties and oral bioavailability of abiraterone acetate

K Parmar, R Patel - BioNanoScience, 2023 - Springer
Abiraterone acetate is a novel antiandrogen drug indicated for prostate cancer. However, it
suffers from low bioavailability owing to poor dissolution properties. The present work was …

[HTML][HTML] A lyophilized surfactant-based rutin formulation with improved physical characteristics and dissolution for oral delivery

H Yusuf, OMN Savitri, R Primaharinastiti… - Saudi Pharmaceutical …, 2023 - Elsevier
Rutin (RUT) is a phytochemical flavonoid with numerous therapeutic potentials including
antihypertension, cardioprotective, neuroprotective, and anti-cancer activities. Its clinical use …

Electrostatic molecular effect of differently charged surfactants on the solubilization capacity and physicochemical properties of salt-caged nanosuspensions …

G Jin, HV Ngo, J Wang, JH Cui, QR Cao, C Park… - International Journal of …, 2022 - Elsevier
In this study, the electrostatic molecular effect of differently charged surfactants on the
solubilization capacity and physicochemical properties of salt-caged nanosuspensions …

An application of citric acid as a carrier for solid dispersion to improve the dissolution and uric acid-lowering effect of kaempferol

D Song, C Xie, R Yang, A Ma, H Zhao, F Zou… - International Journal of …, 2023 - degruyter.com
Kaempferol (KPF) is a flavonoid compound, which has a variety of pharmacological
activities, and widely exists in daily diet. However, its application is limited due to poor …