The genomic simplicity of differentiated cancers derived from thyroid follicular cells offers
unique insights into how oncogenic drivers impact tumour phenotype. Essentially, the main …

Tumours can arise from thyroid follicular cells if they acquire driver mutations that
constitutively activate the MAPK signalling pathway. In addition, a limited set of additional …

Background: Anaplastic thyroid cancer (ATC) is a rare but highly lethal form of thyroid
cancer. Since the guidelines for the management of ATC by the American Thyroid …

Background Risk stratification for patients with differentiated thyroid cancer (DTC) is based
primarily on pathologic tumor characteristics. Accurate preoperative prognostication could …

Differentiated thyroid cancers (DTCs) are primarily initiated by mutations that activate the
MAPK signaling cascade, typically at BRAF or RAS oncoproteins. DTCs can evolve to more …

Simple Summary Thyroid tumors that derive from follicular cells are not a homogeneous
entity, showing variable morphological appearance and different degrees of differentiation …

Background Papillary thyroid cancer (PTC) is the most frequent endocrine tumor.
Radioiodine (RAI) treatment is highly effective in these tumors, but up to 60% of metastatic …

Simple Summary Aggressive variants of papillary thyroid carcinoma (PTC) are associated
with unfavorable clinical outcomes. However, limited data exist on the genetic profile of …

Context Patients with differentiated thyroid cancer (DTC) with distant metastasis (DM) are
usually not recognized as radioactive iodine (RAI)-refractory DTC in a timely manner. The …

The molecular profiling of tumour samples is elucidating the genetic alterations involved in
ATC development, and new preclinical models are under study to define innovative …