Fatty liver diseases can result from common metabolic diseases, as well as from xenobiotic
exposure and excessive alcohol use, all of which have been shown to exert toxic effects on …

Valproic acid (VPA) is an anti-seizure drug that causes idiosyncratic liver injury. 2-propyl-4-
pentenoic acid (Δ 4 VPA), a metabolite of VPA, has been implicated in VPA-induced …

An increasing number of commonly prescribed drugs are known to interfere with
mitochondrial function, which is associated with almost half of all Food and Drug …

Macroautophagy (hereafter referred to as autophagy), a highly conserved metabolic
process, regulates cellular homeostasis by degrading dysfunctional cytosolic constituents …

Simple Summary Mitochondria are crucially important organelles involved in various
metabolic activities, including energy generation. The involvement of mitochondrial …

Mitochondria are critical organelles responsible for the maintenance of cellular energy
homeostasis. Thus, their dysfunction can have severe consequences in cells responsible for …

Clostridioides difficile infection (CDI) appears to be associated with different liver diseases.
C. difficile secretes membrane vesicles (MVs), which may be involved in the development of …

Background Renal ischemia-reperfusion injury (IRI) causes acute kidney injury as well as
liver injury. Renal IRI depletes hepatic antioxidants, promotes hepatic inflammation and …

The synchronous functioning and quality control of organelles ensure cell survival and
function and are essential for maintaining homeostasis. Prolonged exposure to stressors …

The persistence of hepatotoxicity induced by N-acetyl-para-aminophenol (Acetaminophen
or Paracetamol, abbreviated as APAP) as the most common cause of acute liver failure in …