Purpose Radiation-induced fibrosis (RIF) is a long-term side effect of external beam
radiation therapy for the treatment of cancer. It results in a multitude of symptoms that …

Immunotherapy is radically changing the clinical management of patients affected by an
increasingly wide array of tumours. However, not all patients achieve long-term clinical …

Acute radiation damage is most prominent in tissues with rapidly proliferating cells, such as
in epithelial surfaces of the skin or alimentary tract. Symptoms develop when functional cells …

Pulmonary fibrosis is the consequence of a variety of diseases with no satisfying treatment
option. Therapy-induced fibrosis also limits the efficacy of chemotherapy and radiotherapy in …

The central nervous system (CNS) is a major dose-limiting organ in clinical radiotherapy
(XRT). The underlying mechanisms of radiation-induced injury in this organ remain unclear …

The pronounced radiosensitivity of renal tissue limits the total radiotherapeutic dose that can
be applied safely to treatment volumes that include the kidneys. The incidence of clinical …

Radiation pneumopathy is the reaction of the organ lung to radiation effects in various target
cells. It starts as an exudative inflammation, with the clinical picture of interstitial pneumonia …

Radiation-induced pulmonary fibrosis (RIPF) is a common complication in patients with lung
cancer and breast cancer after receiving thoracic radiotherapy. The average incidence of …

Patients with idiopathic pulmonary fibrosis have a high incidence of lung cancer and a
worse prognosis for clinical treatment. A few molecules with antifibrosis properties have …

Purpose: Elevated manganese superoxide dismutase (Sod2) levels have been reported to
be associated with an increasedfrequency of tumor invasion and metastasis in certain …