Bridging barriers: advances and challenges in modeling biological barriers and measuring barrier integrity in organ-on-chip systems

A Ugodnikov, H Persson, CA Simmons - Lab on a Chip, 2024 - pubs.rsc.org
Biological barriers such as the blood–brain barrier, skin, and intestinal mucosal barrier play
key roles in homeostasis, disease physiology, and drug delivery–as such, it is important to …

[HTML][HTML] Establishment and evaluation of on-chip intestinal barrier biosystems based on microfluidic techniques

H Wang, X Li, P Shi, X You, G Zhao - Materials Today Bio, 2024 - Elsevier
As a booming engineering technology, the microfluidic chip has been widely applied for
replicating the complexity of human intestinal micro-physiological ecosystems in vitro …

ROS-responsive nanoparticles targeting inflamed colon for synergistic therapy of inflammatory bowel disease via barrier repair and anti-inflammation

D Wang, Q Jiang, R Shen, L Peng, W Zhou, T Meng… - Nano Research, 2024 - Springer
The destruction of the intestinal barrier is likely to cause an increase in intestinal
permeability and cause pathological damage. Numerous studies have demonstrated that …

[HTML][HTML] Emergent trends in organ-on-a-chip applications for investigating metastasis within tumor microenvironment: A comprehensive bibliometric analysis

C He, F Lu, Y Liu, Y Lei, X Wang, N Tang - Heliyon, 2024 - cell.com
Background With the burgeoning advancements in disease modeling, drug development,
and precision medicine, organ-on-a-chip has risen to the forefront of biomedical research …

From animal models to gut-on-chip: the challenging journey to capture inter-individual variability in chronic digestive disorders

A Kriaa, V Mariaule, C De Rudder, A Jablaoui… - Gut …, 2024 - Taylor & Francis
Chronic digestive disorders are of increasing incidence worldwide with expensive
treatments and no available cure. Available therapeutic schemes mainly rely on symptom …

Dahuang-Wumei decoction protects against hepatic encephalopathy in mice: Behavioural, biochemical, and molecular evidence

Q Liu, X Ba, L Han, J Yan, Z Chen, K Qin, S Tu, P Shen - Phytomedicine, 2024 - Elsevier
Background Disturbance of the blood‒brain barrier (BBB) and associated inflammatory
responses are observed in patients with hepatic encephalopathy (HE) and can cause long …

Barrier Functional Integrity Recording on bEnd. 3 Vascular Endothelial Cells via Transendothelial Electrical Resistance Detection

F Fan, H Jiang, Y Hou, Y Zhang, Q Zhao… - JoVE (Journal of …, 2023 - jove.com
The blood-brain barrier (BBB) is a dynamic physiological structure composed of
microvascular endothelial cells, astrocytes, and pericytes. By coordinating the interaction …

Applications of TEER Detection to Assess Cell Barrier Integrity (Video)| JoVE

F Fan, H Jiang, Y Hou, Y Zhang, Q Zhao… - JoVE (Journal of …, 2023 - jove.com
The blood-brain barrier (BBB) is a dynamic physiological structure composed of
microvascular endothelial cells, astrocytes, and pericytes. By coordinating the interaction …

高磷血症新药Tenapanor 药理作用及临床评价

侯文平, 徐磊, 苏长海 - 中国临床药理学与治疗学, 2023 - manu41.magtech.com.cn
Tenapanor 是一种新型降磷药物, 主要作用于钠/氢交换蛋白3 (NHE3) 起抑制作用,
此外还可以通过下调磷酸钠盐协同转运蛋白(NAPI) 的表达, 从而降低肠道对磷的吸收 …

[PDF][PDF] DEVELOPMENT AND TESTING OF IN VITRO MEASUREMENT SYSTEM FOR EPITHELIAL BARRIER DYNAMICS

S Nymark, N Milicevic - 2024 - trepo.tuni.fi
DEVELOPMENT AND TESTING OF IN VITRO MEASUREMENT SYSTEM FOR EPITHELIAL
BARRIER DYNAMICS Page 1 Julia Harju DEVELOPMENT AND TESTING OF IN VITRO …