Chemokines are a large family of small secreted proteins that have fundamental roles in
organ development, normal physiology, and immune responses upon binding to their …

DNA methylation is one of the most essential epigenetic mechanisms to regulate gene
expression. DNA methyltransferases (DNMTs) play a vital role in DNA methylation in the …

Background The tumor immune microenvironment (TIME) has been recognized to be an
imperative factor facilitating the acquisition of many cancer-related hallmarks and is a critical …

KRAS mutation is a common driver in solid tumors, and KRAS-mutated tumors are relatively
resistant to radiotherapy. Therefore, we investigated the combined effect of radiation and …

Background: Ovarian Serous Adenocarcinoma (OV) is a malignant tumor originating from
epithelial cells and one of the most common causes of death from gynecological cancers. In …

Background Through microarray results, we found that the CXC motif chemokine ligand 11
(CXCL11) was negatively regulated by mediator complex subunit 19 (MED19), a protumour …

Objective Recent molecular profiling revealed that cancer-associated fibroblasts (CAFs) are
essential for matrix remodeling and tumor progression. Our study aimed to investigate the …

Background The chemokines, CXCL12 and CXCL11, are upregulated in tumors from many
organs and control their progression. CXCL12 and CXCL11 affect tumor cell functions by …

Background Meningiomas are mainly benign brain tumors, although about 20% of
histologically benign cases are clinically aggressive and recur after resection. We …

Chemokines are chemotactic-competent molecules composed of a family of small cytokines,
playing a key role in regulating tumor progression. The roles of chemokines in antitumor …