Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

Cystathionine-β-synthase (CBS), the first (and rate-limiting) enzyme in the transsulfuration
pathway, is an important mammalian enzyme in health and disease. Its biochemical …

Reactive sulfur species, or persulfides and polysulfides, such as cysteine hydropersulfide
and glutathione persulfide, are endogenously produced in abundance in both prokaryotes …

Significance: Cancer represents a major socioeconomic problem; there is a significant need
for novel therapeutic approaches targeting tumor-specific pathways. Recent Advances: In …

This review covers briefly the major conditions, genetic and non‐genetic, sometimes leading
to abnormally elevated methionine, with emphasis on recent developments. A major aim is …

The integrated stress response mediated by eukaryotic translation initiation factor 2α (eIF2α)
phosphorylation maintains cellular homeostasis under endoplasmic reticulum (ER) stress …

Melanoma is one of the cancers of fastest-rising incidence in the world. Inducible nitric oxide
synthase (iNOS) is overexpressed in melanoma and other cancers, and previous data …

Homocysteine (Hcy), produced physiologically in all cells, is an intermediate metabolite of
methionine and cysteine metabolism. Hyperhomocysteinemia (HHcy) resulting from an in …

Hydrogen sulfide is an essential gasotransmitter associated with numerous pathologies. We
assert that hydrogen sulfide plays an important role in regulating macrophage function in …

The gut is a selective barrier that not only allows the translocation of nutrients from food, but
also microbe-derived metabolites to the systemic circulation that flows through the liver …