Alzheimer's Disease (AD) is the major form of senile dementia, characterized by neuronal
loss, extracellular deposits, and neurofibrillary tangles. It is accompanied by a loss of …

Biological membranes show lateral and transverse asymmetric lipid distribution. Cholesterol
(Chol) localizes in both hemilayers, but in the external one it is mostly condensed in lipid …

Long-term potentiation (LTP) of synaptic transmission represents the cellular basis of
learning and memory. Astrocytes have been shown to regulate synaptic transmission and …

There is a great demand for long-term cellular tracers because of their great importance in
monitoring biological processes, pathological pathways, therapeutic effects, etc. Herein we …

We produced CA1-specific NMDA receptor 1 subunit-knockout (CA1-KO) mice to determine
the NMDA receptor dependence of nonspatial memory formation and of experience-induced …

Neurons, the basic information processing units of the nervous system, are characterized by
a complex polar morphology which is essential for their function. To attain their precise …

Fear conditioning is a valuable behavioral paradigm for studying the neural basis of
emotional learning and memory. The lateral nucleus of the amygdala (LA) is a crucial site of …

Extensive evidence supports the view that cholinergic mechanisms modulate learning and
memory formation. This paper reviews evidence for cholinergic regulation of multiple …

Memory for past events may be based on retrieval accompanied by specific contextual
details (recollection) or on the feeling that an item is old (familiarity) or new (novelty) in the …

Multiple recent human imaging studies have suggested that the structure of the brain can
change with learning. To investigate the mechanism behind such structural plasticity, we …