Selective separation and enrichment of peptides for MS analysis using the microspheres composed of Fe3O4@ nSiO2 core and perpendicularly aligned mesoporous …

H Chen, S Liu, H Yang, Y Mao, C Deng, X Zhang… - …, 2010 - Wiley Online Library
In this work, we report the development of a novel enrichment protocol for peptides by using
the microspheres composed of Fe3O4@ nSiO2 Core and perpendicularly aligned …

Mice lacking proSAAS display alterations in emotion, consummatory behavior and circadian entrainment

DK Aryal, RM Rodriguiz, NL Nguyen… - Genes, Brain and …, 2022 - Wiley Online Library
ProSAAS is a neuroendocrine protein that is cleaved by neuropeptide‐processing enzymes
into more than a dozen products including the bigLEN and PEN peptides, which bind and …

Top-down proteomics with mass spectrometry imaging: a pilot study towards discovery of biomarkers for neurodevelopmental disorders

H Ye, R Mandal, A Catherman, PM Thomas… - PloS one, 2014 - journals.plos.org
In the developing mammalian brain, inhibition of NMDA receptor can induce widespread
neuroapoptosis, inhibit neurogenesis and cause impairment of learning and memory …

[HTML][HTML] The effects of aging on biosynthetic processes in the rat hypothalamic osmoregulatory neuroendocrine system

MP Greenwood, M Greenwood, EV Romanova… - Neurobiology of …, 2018 - Elsevier
Elderly people exhibit a diminished capacity to cope with osmotic challenges such as
dehydration. We have undertaken a detailed molecular analysis of arginine vasopressin …

The hypothalamic‐neurohypophyseal system: from genome to physiology

D Murphy, A Konopacka, C Hindmarch… - Journal of …, 2012 - Wiley Online Library
The elucidation of the genomes of a large number of mammalian species has produced a
huge amount of data on which to base physiological studies. These endeavours have also …

Circadian integration of glutamatergic signals by little SAAS in novel suprachiasmatic circuits

N Atkins Jr, JW Mitchell, EV Romanova, DJ Morgan… - PloS one, 2010 - journals.plos.org
Background Neuropeptides are critical integrative elements within the central circadian
clock in the suprachiasmatic nucleus (SCN), where they mediate both cell-to-cell …

A peptidomics strategy for discovering endogenous bioactive peptides

K Sasaki, N Takahashi, M Satoh… - Journal of proteome …, 2010 - ACS Publications
Peptide hormones and neuropeptides constitute an important class of naturally occurring
peptides that are generated from precursor proteins by limited proteolytic processing. An …

Neuropeptidomic analysis of a genetically defined cell type in mouse brain and pituitary

LD Fricker, AK Tashima, AK Fakira… - Cell chemical …, 2021 - cell.com
Neuropeptides and peptide hormones are important cell-cell signaling molecules that
mediate many physiological processes. Unlike classic neurotransmitters, peptides undergo …

[HTML][HTML] Discovering new bioactive neuropeptides in the striatum secretome using in vivo microdialysis and versatile proteomics

B Bernay, MC Gaillard, V Guryča, A Emadali… - Molecular & Cellular …, 2009 - Elsevier
The striatum, a major component of the brain basal nuclei, is central for planning and
executing voluntary movements and undergoes lesions in neurodegenerative disorders …

Neuropeptidomics of the rat habenular nuclei

N Yang, KDB Anapindi, SS Rubakhin… - Journal of proteome …, 2018 - ACS Publications
Conserved across vertebrates, the habenular nuclei are a pair of small symmetrical
structures in the epithalamus. The nuclei functionally link the forebrain and midbrain by …