Brain GLP‐1 and the regulation of food intake: GLP‐1 action in the brain and its implications for GLP‐1 receptor agonists in obesity treatment

S Trapp, DI Brierley - British Journal of Pharmacology, 2022 - Wiley Online Library
This review considers the similarities and differences between the physiological systems
regulated by gut‐derived and neuronally produced glucagon‐like peptide 1 (GLP‐1). It …

Weight loss between glucagon‐like peptide‐1 receptor agonists and bariatric surgery in adults with obesity: A systematic review and meta‐analysis

S Sarma, P Palcu - Obesity, 2022 - Wiley Online Library
Abstract Objective Glucagon‐like peptide‐1 (GLP‐1) receptor agonists recently
demonstrated 15% to 20% weight loss in adults with obesity, a range which has previously …

Patient-reported outcomes, weight loss, and remission of type 2 diabetes 3 years after gastric bypass and sleeve gastrectomy (Oseberg); a single-centre, randomised …

M Svanevik, J Lorentzen, H Borgeraas… - The Lancet Diabetes & …, 2023 - thelancet.com
Background Little is known about the comparative effects of various bariatric procedures on
patient-reported outcomes. We aimed to compare 3-year effects of gastric bypass and …

Therapeutic potential of GLP-2 analogs in gastrointestinal disorders: current knowledge, nutritional aspects, and future perspectives

D Kounatidis, NG Vallianou, D Tsilingiris… - Current Nutrition …, 2022 - Springer
Abstract Purpose of Review Although Glucagon-like peptide (GLP)-1 receptor agonists have
been used for almost two decades in the treatment of diabetes mellitus type 2 and, lately, in …

Postbariatric surgery hypoglycemia: nutritional, pharmacological and surgical perspectives

G Rossini, R Risi, L Monte, B Sancetta… - Diabetes/Metabolism …, 2024 - Wiley Online Library
Post‐bariatric hypoglycaemia (PBH) is a metabolic complication of bariatric surgery (BS),
consisting of low post‐prandial glucose levels in patients having undergone bariatric …

Functional screening and rational design of compounds targeting GPR132 to treat diabetes

JL Wang, XD Dou, J Cheng, MX Gao, GF Xu… - Nature …, 2023 - nature.com
Chronic inflammation due to islet-residing macrophages plays key roles in the development
of type 2 diabetes mellitus. By systematically profiling intra-islet lipid–transmembrane …

The efficacy of GLP‐1RAs for the management of postprandial hypoglycemia following bariatric surgery: a systematic review

DC Llewellyn, H Logan Ellis, SJB Aylwin, E Oštarijaš… - …, 2023 - Wiley Online Library
Objective Postprandial hyperinsulinemic hypoglycemia with neuroglycopenia is an
increasingly recognized complication of Roux‐en‐Y gastric bypass and gastric sleeve …

Dumping Syndrome: Pragmatic Treatment Options and Experimental Approaches for Improving Clinical Outcomes

GMC Masclee, AAM Masclee - Clinical and experimental …, 2023 - Taylor & Francis
Dumping syndrome is a common complication after esophageal, gastric and bariatric
surgery and has a significant negative impact on the quality of life of patients. This narrative …

Surgical treatment of obesity. Special mention to roux-en-Y gastric bypass and vertical gastrectomy

MJ Luesma, J Fernando, I Cantarero… - Frontiers in …, 2022 - frontiersin.org
Introduction The prevalence of obesity has increased exponentially in recent decades, being
one of the diseases that most affects global health. It is a chronic disease associated with …

Metabolic effects of an oral glucose tolerance test compared to the mixed meal tolerance tests: a narrative review

M Lages, R Barros, P Moreira, MP Guarino - Nutrients, 2022 - mdpi.com
The oral glucose tolerance test (OGTT) is recommended for assessing abnormalities in
glucose homeostasis. Recognised as the gold standard test for diagnosing diabetes, the …