Hereditary angio-oedema is caused by a heterozygous deficiency of C1 inhibitor. This
inhibitor regulates several inflammatory pathways, and patients with hereditary angio …

Background The consensus documents published to date on hereditary angioedema with
C1 inhibitor deficiency (C1‐INH‐HAE) have focused on adult patients. Many of the previous …

To cite this article: Cicardi M, Bork K, Caballero T, Craig T, Li HH, Longhurst H, Reshef A,
Zuraw B on behalf of HAWK (Hereditary Angioedema International Working Group) …

Antibodies have proved to be a valuable mode of therapy for numerous diseases, mainly
owing to their high target binding affinity and specificity. Unfortunately, antibodies are also …

Tissue kallikreins are a family of fifteen secreted serine proteases encoded by the largest
protease gene cluster in the human genome. In the past decade, substantial progress has …

Coupling the tools of synthetic biology with traditional molecular genetic techniques can
enable the rapid prototyping and optimization of yeast strains. While the era of yeast …

Background Hereditary angioedema with C1 inhibitor deficiency is characterized by
recurrent, unpredictable swelling episodes caused by uncontrolled plasma kallikrein …

Successful screening campaigns depend on large and structurally diverse collections of
compounds. In macrocycle screening, variation of the molecular scaffold is important for …

Background Recurrent angioedema is a frequent clinical problem characterized by
unpredictably and rapidly occurring cutaneous and mucosal swellings. These swellings may …

BACKGROUND: There are a limited number of publications on the management of
gynecologic/obstetric events in female patients with hereditary angioedema caused by C1 …