Episodic and recurrent local cutaneous or mucosal swelling are key features of
angioedema. The vasoactive agents histamine and bradykinin are highly implicated as …

To cite this article: Craig TJ, Bewtra AK, Bahna SL, Hurewitz D, Schneider LC, Levy RJ, Moy
JN, Offenberger J, Jacobson KW, Yang WH, Eidelman F, Janss G, Packer FR, Rojavin MA …

Background Hereditary angioedema (HAE) is a rare, debilitating, and potentially life-
threatening disease characterized by recurrent edema attacks. Important advances in HAE …

The contact system is a plasma protease cascade that is initiated by coagulation factor XII
activation on cardiovascular cells. The system starts procoagulant and proinflammatory …

Cardiovascular disease, including stroke, myocardial infarction, and venous
thromboembolism, is one of the leading causes of morbidity and mortality worldwide …

Thrombolytic therapy using tissue plasminogen activator (tPA) in acute stroke is associated
with increased risks of cerebral hemorrhagic transformation and angioedema. Although …

Background Acquired angioedema due to C1-inhibitor deficiency (C1-INH-AAE) is a rare
disease with no prevalence data or approved therapies. Objective To report data on patients …

Angioedema is defined as local, noninflammatory, self-limiting edema that is circumscribed
owing to increased leakage of plasma from the capillaries located in the deep layers of the …

Hereditary angioedema (HAE) is a rare disease that causes episodic attacks of
subcutaneous and submucosal edema, which can be painful, incapacitating, and potentially …

Objective Hereditary angioedema (HAE) is a rare genetic disease characterized by long-
term recurrent attacks of subcutaneous or submucosal edema in different parts of the body …