Hereditary angioedema is a rare, genetic disorder characterized by painful, debilitating and
potentially life-threatening angioedema attacks in subcutaneous and submucosal tissue …

Plasma kallikrein (PKal) belongs to the family of trypsin-like serine proteases. The
expression of PKal is associated with multiple physiological systems or pathways such as …

Hereditary angioedema (HAE) caused by C1-esterase inhibitor deficiency is an autosomal-
dominant disease resulting from a mutation in the C1-inhibitor gene. HAE is characterized …

Background: The kallikrein kinin system (KKS) is an established pharmacological target for
the treatment and prevention of attacks in hereditary angioedema (HAE). Proteolytic …

Hereditary angioedema (HAE) is a rare disease characterized by sudden and often
unprovoked episodes of swelling that can be potentially life-threatening when it involves the …

Hereditary angioedema (HAE) is an autosomal dominant disease caused by a deficiency in
functional C1 inhibitor affecting an estimated 1 in 50,000 individuals in the United States …

Allergic disease is among the most common pathologies worldwide and its prevalence has
constantly increased up to the present days, even if according to the most recent data it …

Edema is tissue swelling and is a common symptom in a variety of diseases. Edema form
due to accumulation of fluids, either through reduced drainage or increased vascular …

Availability of effective treatment for acute attacks is expected to transform the care of
hereditary angioedema (HAE) patients. We felt that it would be of interest to test these …

Background Hereditary angioedema with C1 inhibitor deficiency (C1‐INH‐HAE) is a rare
inherited genetic disease characterized by recurrent swelling episodes of the skin …