Angioedema: Classification, management and emerging therapies for the perioperative physician

L Misra, N Khurmi, TL Trentman - Indian Journal of Anaesthesia, 2016 - journals.lww.com
Angioedema is a rare condition which manifests as sudden localised, non-pitting swelling of
certain body parts including skin and mucous membranes. It is vital that anaesthesiologists …

Tolerability and effectiveness of 17-α-alkylated androgen therapy for hereditary angioedema: a re-examination

BL Zuraw, DK Davis, AJ Castaldo… - The Journal of Allergy …, 2016 - Elsevier
Background Hereditary angioedema (HAE) is a genetic disorder clinically characterized by
recurrent attacks of subcutaneous and mucosal swelling. 17-α-Alkylated androgens (AA) …

A reverse binding motif that contributes to specific protease inhibition by antibodies

EL Schneider, MS Lee, A Baharuddin, DH Goetz… - Journal of molecular …, 2012 - Elsevier
The type II transmembrane serine protease family consists of 18 closely related serine
proteases that are implicated in multiple functions. To identify selective, inhibitory antibodies …

Protein engineering for cardiovascular therapeutics: untapped potential for cardiac repair

SM Jay, RT Lee - Circulation research, 2013 - Am Heart Assoc
A number of new and innovative approaches for repairing damaged myocardium are
currently undergoing investigation, with several encouraging results. In addition to the …

The role of plasma kallikrein–kinin pathway in the development of diabetic retinopathy: Pathophysiology and therapeutic approaches

M Abdulaal, NMN Haddad, JK Sun… - Seminars in …, 2016 - Taylor & Francis
Diabetic retinal disease is characterized by a series of retinal microvascular changes and
increases in retinal vascular permeability that lead to development of diabetic retinopathy …

Pediatric hereditary angioedema

AJ MacGinnitie - Pediatric Allergy and Immunology, 2014 - Wiley Online Library
Hereditary angioedema (HAE) is a lifelong illness characterized by recurrent swelling of the
skin, intestinal tract, and, ominously, the upper airway. It is caused by inadequate activity of …

[HTML][HTML] Diretrizes brasileiras para o diagnóstico e tratamento do angioedema hereditário-2017

P Giavina-Bianchi, LK Arruda, MV Aun… - Arquivos de Asma …, 2017 - aaai-asbai.org.br
RESUMO O angioedema hereditário é uma doença autossômica dominante caracterizada
por crises de edema com o envolvimento de múltiplos órgaos. A doença é desconhecida …

Lanadelumab for the prophylactic treatment of hereditary angioedema with C1 inhibitor deficiency: a review of preclinical and phase I studies

PJ Busse, H Farkas, A Banerji, WR Lumry… - BioDrugs, 2019 - Springer
Hereditary angioedema (HAE) with C1 esterase inhibitor (C1-INH) deficiency (C1-INH-HAE)
is a rare disease characterized by diminished levels or dysfunctional activity of C1-INH …

A decade of change: recent developments in pharmacotherapy of hereditary angioedema (HAE)

K Bork - Clinical reviews in allergy & immunology, 2016 - Springer
Hereditary angioedema (HAE) due to C1 esterase inhibitor (C1-INH) deficiency (HAE-C1-
INH) is a rare but medically significant disease that can be associated with considerable …

Kallikrein inhibitors for angioedema: the progress of preclinical and early phase studies

H Farkas, Z Balla - Expert opinion on investigational drugs, 2024 - Taylor & Francis
Introduction Hereditary angioedema (HAE) is a rare genetic disorder characterized by
recurrent edema and predominantly caused by the dysregulation of the kinin-kallikrein …