Endoplasmic reticulum stress signals in the tumour and its microenvironment
X Chen, JR Cubillos-Ruiz - Nature Reviews Cancer, 2021 - nature.com
Protein handling, modification and folding in the endoplasmic reticulum (ER) are tightly
regulated processes that determine cell function, fate and survival. In several tumour types …
regulated processes that determine cell function, fate and survival. In several tumour types …
Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases
Cardiovascular diseases (CVDs), such as ischaemic heart disease, cardiomyopathy,
atherosclerosis, hypertension, stroke and heart failure, are among the leading causes of …
atherosclerosis, hypertension, stroke and heart failure, are among the leading causes of …
Mechanisms, regulation and functions of the unfolded protein response
C Hetz, K Zhang, RJ Kaufman - Nature reviews Molecular cell biology, 2020 - nature.com
Cellular stress induced by the abnormal accumulation of unfolded or misfolded proteins at
the endoplasmic reticulum (ER) is emerging as a possible driver of human diseases …
the endoplasmic reticulum (ER) is emerging as a possible driver of human diseases …
Sublethal cytochrome c release generates drug-tolerant persister cells
Drug-tolerant persister cells (persisters) evade apoptosis upon targeted and conventional
cancer therapies and represent a major non-genetic barrier to effective cancer treatment …
cancer therapies and represent a major non-genetic barrier to effective cancer treatment …
Endoplasmic reticulum stress in liver diseases
The endoplasmic reticulum (ER) is an intracellular organelle that fosters the correct folding
of linear polypeptides and proteins, a process tightly governed by the ER‐resident enzymes …
of linear polypeptides and proteins, a process tightly governed by the ER‐resident enzymes …
ER stress and UPR in Alzheimer's disease: mechanisms, pathogenesis, treatments
Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by
gradual loss of memory and cognitive function, which constitutes a heavy burden on the …
gradual loss of memory and cognitive function, which constitutes a heavy burden on the …
[HTML][HTML] Endoplasmic reticulum stress signaling in cancer cells
SA Oakes - The American journal of pathology, 2020 - Elsevier
To survive, cancer cells must resist numerous internal and environmental insults associated
with neoplasia that jeopardize proteostasis within the endoplasmic reticulum (ER). Solid and …
with neoplasia that jeopardize proteostasis within the endoplasmic reticulum (ER). Solid and …
Control of immune cell function by the unfolded protein response
G Di Conza, PC Ho, JR Cubillos-Ruiz… - Nature Reviews …, 2023 - nature.com
Initiating and maintaining optimal immune responses requires high levels of protein
synthesis, folding, modification and trafficking in leukocytes, which are processes …
synthesis, folding, modification and trafficking in leukocytes, which are processes …
Hypoxia, endoplasmic reticulum stress and chemoresistance: dangerous liaisons
M Akman, DC Belisario, IC Salaroglio… - Journal of Experimental …, 2021 - Springer
Solid tumors often grow in a micro-environment characterized by< 2% O 2 tension. This
condition, together with the aberrant activation of specific oncogenic patwhays, increases …
condition, together with the aberrant activation of specific oncogenic patwhays, increases …
The PERKs of mitochondria protection during stress: insights for PERK modulation in neurodegenerative and metabolic diseases
LM Almeida, BR Pinho, MR Duchen… - Biological …, 2022 - Wiley Online Library
Protein kinase RNA‐like ER kinase (PERK) is an endoplasmic reticulum (ER) stress sensor
that responds to the accumulation of misfolded proteins. Once activated, PERK initiates …
that responds to the accumulation of misfolded proteins. Once activated, PERK initiates …