Recent trends in the development of hydrogel therapeutics for the treatment of central nervous system disorders

Q Li, X Shao, X Dai, Q Guo, B Yuan, Y Liu… - NPG Asia …, 2022 - nature.com
The central nervous system (CNS) controls the acquisition and processing of peripheral
information to manage the behaviors of organisms. CNS disorders, including CNS injuries …

Naturally occurring biological macromolecules-based hydrogels: Potential biomaterials for peripheral nerve regeneration

H Samadian, H Maleki, A Fathollahi, M Salehi… - International journal of …, 2020 - Elsevier
Despite the recent advances in the treatment strategies of peripheral nerve system defects,
peripheral nerve injury (PNI) is still one of the most important health issues with increasing …

Directing induced pluripotent stem cell derived neural stem cell fate with a three-dimensional biomimetic hydrogel for spinal cord injury repair

L Fan, C Liu, X Chen, Y Zou, Z Zhou, C Lin… - … applied materials & …, 2018 - ACS Publications
Current treatment approaches for spinal cord injuries (SCIs) are mainly based on cellular
transplantation. Induced pluripotent stem cells (iPSCs) without supply constraints and ethical …

[HTML][HTML] An injectable and self-healing hydrogel with controlled release of curcumin to repair spinal cord injury

J Luo, X Shi, L Li, Z Tan, F Feng, J Li, M Pang, X Wang… - Bioactive materials, 2021 - Elsevier
The harsh local micro-environment following spinal cord injury (SCI) remains a great
challenge for neural regeneration. Local reconstitution of a favorable micro-environment by …

A Bioinspired Injectable, Adhesive, and Self‐Healing Hydrogel with Dual Hybrid Network for Neural Regeneration after Spinal Cord Injury

L Xiao, P Xie, J Ma, K Shi, Y Dai, M Pang… - Advanced …, 2023 - Wiley Online Library
Hydrogel‐based regenerated scaffolds show promise as a platform for neural regeneration
following spinal cord injury (SCI). Nevertheless, the persistent problem of poor mechanical …

Regenerative rehabilitation with conductive biomaterials for spinal cord injury

EA Kiyotake, MD Martin, MS Detamore - Acta biomaterialia, 2022 - Elsevier
The individual approaches of regenerative medicine efforts alone and rehabilitation efforts
alone have not yet fully restored function after severe spinal cord injury (SCI). Regenerative …

Recent advances in the application of two-dimensional nanomaterials for neural tissue engineering and regeneration

A Halim, KY Qu, XF Zhang… - ACS Biomaterials Science …, 2021 - ACS Publications
The complexity of the nervous system structure and function, and its slow regeneration rate,
makes it more difficult to treat compared to other tissues in the human body when an injury …

[HTML][HTML] Functional hydrogels as therapeutic tools for spinal cord injury: New perspectives on immunopharmacological interventions

CM Walsh, JK Wychowaniec, DF Brougham… - Pharmacology & …, 2022 - Elsevier
Spinal cord injury (SCI) is a complex medical and psychological challenge for which there is
no curative therapy currently available. Despite major progress in pharmacological and …

[PDF][PDF] Synthetic polymer scaffolds for soft tissue engineering.

O Janoušková - Physiological research, 2018 - pdfs.semanticscholar.org
Tissue engineering (TE) and regenerative medicine are progressively developed areas due
to many novel tissue replacements and implementation strategies. Increasing knowledge …

Injectable extracellular matrix hydrogels as scaffolds for spinal cord injury repair

D Tukmachev, S Forostyak, Z Koci… - … Engineering Part A, 2016 - liebertpub.com
Restoration of lost neuronal function after spinal cord injury (SCI) still remains a big
challenge for current medicine. One important repair strategy is bridging the SCI lesion with …