Despite considerable advancements that shattered previously held dogmas about the
metastatic cascade, the evolution of therapies to treat metastatic disease has not kept up. In …

Research in the last few years has revealed a sophisticated interaction network between
multiple bone marrow cells that regulate different hematopoietic stem cell (HSC) properties …

The bone marrow (BM) microenvironment regulates the properties of healthy hematopoietic
stem cells (HSCs) localized in specific niches. Two distinct microenvironmental niches have …

The bone marrow is the home of hematopoiesis and is therefore a hotspot for the
development of hematopoietic diseases. Complex interactions between the bone marrow …

Objectives: To summarize the effects of the bone marrow niche on hematopoiesis and
leukemogenesis and discuss the chemotherapy resistance that can arise from interactions …

Bone marrow (BM) is a highly complex tissue that provides important regulatory signals to
orchestrate hematopoiesis. Resident and transient cells occupy and interact with some well …

The bone marrow is a complex tissue in which heterogeneous populations of stromal cells
interact with hematopoietic cells to dynamically respond to organismal needs in defense …

The bone marrow (BM) vascular niche microenvironments harbor stem and progenitor cells
of various lineages. Bone angiogenesis is distinct and involves tissue-specific signals. The …

Background Acute myeloid leukemia (AML) is a hematological malignancy that remains a
therapeutic challenge due to the high incidence of disease relapse. To better understand …

Ex vivo studies of human disease, such as acute myeloid leukemia, are generally limited to
the analysis of two-dimensional cultures which often misinterpret the effectiveness of …