The endosteal bone marrow niche and vascular endothelial cells provide sanctuaries for
leukemic cells. In murine chronic myeloid leukemia (CML) CD44 on leukemia cells and E …

Extracellular vesicle (EV) trafficking provides for a constitutive mode of cell-cell
communication within tissues and between organ systems. Different EV subtypes have been …

Acute myeloid leukemia (AML) is a heterogeneous disease in which a variety of distinct
genetic alterations might occur. Recent attempts to identify the leukemia stem-like cells …

Knowledge about the hematopoietic niche has evolved considerably in recent years, in
particular through in vitro analyzes, mouse models and the use of xenografts. Its complexity …

Cell adhesion is a process through which cells interact with and attach to neighboring cells
or matrix using specialized surface cell adhesion molecules (AMs). Adhesion plays an …

One of the greatest challenges in treating acute myeloid leukemia (AML) is chemotherapy
refractory disease. Previously, we demonstrated a novel mechanism whereby AML-induced …

Vascular endothelial cells, forming the inner wall of the blood vessels, participate in the
body's pathological and physiological processes of immunity, tumors, and infection. In …

The myelodysplastic syndromes (MDS) are a diverse group of clonal hematopoietic
malignancies characterized by ineffective hematopoiesis, progressive bone marrow (BM) …

Both the cascade whereby a blood-borne cell enters a tissue and the anchoring of
hematopoietic stem/progenitor cells (HSPCs) within bone marrow critically pivots on cell-cell …

The concept of 'niche'has become a focus of attention in hematologic malignancies
including acute myeloid leukemia (AML). Similar to normal hematopoietic stem cells, AML …