[HTML][HTML] The zebrafish as a model to study intestinal inflammation

S Brugman - Developmental & Comparative Immunology, 2016 - Elsevier
Starting out as a model for developmental biology, during the last decade, zebrafish have
also gained the attention of the immunologists and oncologists. Due to its small size, high …

Modeling inflammation in zebrafish for the development of anti-inflammatory drugs

Y Xie, AH Meijer, MJM Schaaf - Frontiers in cell and developmental …, 2021 - frontiersin.org
Dysregulation of the inflammatory response in humans can lead to various inflammatory
diseases, like asthma and rheumatoid arthritis. The innate branch of the immune system …

Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration

TM Tsarouchas, D Wehner, L Cavone, T Munir… - Nature …, 2018 - nature.com
Spinal cord injury leads to a massive response of innate immune cells in non-regenerating
mammals, but also in successfully regenerating zebrafish. However, the role of the immune …

Studying the fate of tumor extracellular vesicles at high spatiotemporal resolution using the zebrafish embryo

V Hyenne, S Ghoroghi, M Collot, J Bons, G Follain… - Developmental cell, 2019 - cell.com
Tumor extracellular vesicles (EVs) mediate the communication between tumor and stromal
cells mostly to the benefit of tumor progression. Notably, tumor EVs travel in the …

Inflammatory cytokines in type 2 diabetes mellitus as facilitators of hypercoagulation and abnormal clot formation

SN Randeria, GJA Thomson, TA Nell, T Roberts… - Cardiovascular …, 2019 - Springer
Background The global burden of type 2 diabetes mellitus (T2DM), together with the
presence of cardiovascular risk in this population, is reaching pandemic levels. A prominent …

Metformin modulates innate immune-mediated inflammation and early progression of NAFLD-associated hepatocellular carcinoma in zebrafish

S de Oliveira, RA Houseright, AL Graves… - Journal of …, 2019 - Elsevier
Background & Aims Non-alcoholic fatty liver disease/non-alcoholic steatohepatitis
(NAFLD/NASH) is an increasing clinical problem associated with progression to …

Commensal bacteria‐immunity crosstalk shapes mucosal homeostasis in teleost fish

YY Yu, LG Ding, ZY Huang, HY Xu… - Reviews in …, 2021 - Wiley Online Library
Fish harbour complex and dynamic microbiota in their mucosal surfaces. Due to the vital role
of commensal microbiota in many biological functions including growth enhancement …

Mechanisms of fish macrophage antimicrobial immunity

L Grayfer, B Kerimoglu, A Yaparla… - Frontiers in …, 2018 - frontiersin.org
Overcrowding conditions and temperatures shifts regularly manifest in large-scale infections
of farmed fish, resulting in economic losses for the global aquaculture industries. Increased …

Zebrafish as a preclinical in vivo screening model for nanomedicines

S Sieber, P Grossen, J Bussmann, F Campbell… - Advanced drug delivery …, 2019 - Elsevier
The interactions of nanomedicines with biological environments is heavily influenced by
their physicochemical properties. Formulation design and optimization are therefore key …

Specific macrophage populations promote both cardiac scar deposition and subsequent resolution in adult zebrafish

L Bevan, ZW Lim, B Venkatesh, PR Riley… - Cardiovascular …, 2020 - academic.oup.com
Aims A robust inflammatory response to tissue injury is a necessary part of the repair
process but the deposition of scar tissue is a direct downstream consequence of this …