Crosstalk between oxidative stress and inflammatory liver injury in the pathogenesis of alcoholic liver disease

YM Yang, YE Cho, S Hwang - International journal of molecular sciences, 2022 - mdpi.com
Alcoholic liver disease (ALD) is characterized by the injury, inflammation, and scarring in the
liver owing to excessive alcohol consumption. Currently, ALD is a leading cause for liver …

Biological Properties of Vitamins of the B-Complex, Part 1: Vitamins B1, B2, B3, and B5

M Hrubša, T Siatka, I Nejmanová, M Vopršalová… - Nutrients, 2022 - mdpi.com
This review summarizes the current knowledge on essential vitamins B1, B2, B3, and B5.
These B-complex vitamins must be taken from diet, with the exception of vitamin B3, that can …

[HTML][HTML] Population-level risks of alcohol consumption by amount, geography, age, sex, and year: a systematic analysis for the Global Burden of Disease Study 2020

D Bryazka, MB Reitsma, MG Griswold, KH Abate… - The Lancet, 2022 - thelancet.com
Background The health risks associated with moderate alcohol consumption continue to be
debated. Small amounts of alcohol might lower the risk of some health outcomes but …

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

M Liu, Y Jiang, R Wedow, Y Li, DM Brazel, F Chen… - Nature …, 2019 - nature.com
Tobacco and alcohol use are leading causes of mortality that influence risk for many
complex diseases and disorders. They are heritable, and etiologically related, behaviors that …

Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

RK Walters, R Polimanti, EC Johnson… - Nature …, 2018 - nature.com
Liability to alcohol dependence (AD) is heritable, but little is known about its complex
polygenic architecture or its genetic relationship with other disorders. To discover loci …

Alcohol dehydrogenases, aldehyde dehydrogenases, and alcohol use disorders: a critical review

HJ Edenberg, JN McClintick - Alcoholism: Clinical and …, 2018 - Wiley Online Library
Alcohol use disorders (AUDs) are complex traits, meaning that variations in many genes
contribute to the risk, as does the environment. Although the total genetic contribution to risk …

[PDF][PDF] Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data

MV Holmes, CE Dale, L Zuccolo, RJ Silverwood, Y Guo… - Bmj, 2014 - bmj.com
Objective To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as
an instrument to investigate the causal role of alcohol in cardiovascular disease. Design …

Alcohol metabolism

AI Cederbaum - Clinics in liver disease, 2012 - liver.theclinics.com
1. Learn how the body disposes of alcohol and its metabolites. 2. Discern some of the factors
that influence this process. 3. Learn how alcohol influences the metabolism of nutrients and …

Genetics of substance use disorders in the era of big data

J Gelernter, R Polimanti - Nature Reviews Genetics, 2021 - nature.com
Substance use disorders (SUDs) are conditions in which the use of legal or illegal
substances, such as nicotine, alcohol or opioids, results in clinical and functional …

Alcohol addiction, gut microbiota, and alcoholism treatment: a review

SC Wang, YC Chen, SJ Chen, CH Lee… - International journal of …, 2020 - mdpi.com
Alcohol addiction is a leading risk factor for personal death and disability. In 2016, alcohol
use caused 2.2% of female deaths and 6.8% of male deaths, and disability-adjusted life …