Epigenetic control
GP Delcuve, M Rastegar… - Journal of cellular …, 2009 - Wiley Online Library
Epigenetics refers to mitotically and/or meiotically heritable variations in gene expression
that are not caused by changes in DNA sequence. Epigenetic mechanisms regulate all …
that are not caused by changes in DNA sequence. Epigenetic mechanisms regulate all …
Environmental and genetic contributions to diabetes
J Tremblay, P Hamet - Metabolism, 2019 - Elsevier
Diabetes mellitus (DM) is a heterogeneous group of disorders characterized by persistent
hyperglycemia. Its two most common forms are type 1 diabetes (T1D) and type 2 diabetes …
hyperglycemia. Its two most common forms are type 1 diabetes (T1D) and type 2 diabetes …
Transgenerational Glucose Intolerance With Igf2/H19 Epigenetic Alterations in Mouse Islet Induced by Intrauterine Hyperglycemia
GL Ding, FF Wang, J Shu, S Tian, Y Jiang, D Zhang… - Diabetes, 2012 - Am Diabetes Assoc
Gestational diabetes mellitus (GDM) has been shown to be associated with high risk of
diabetes in offspring. However, the mechanisms involved and the possibilities of …
diabetes in offspring. However, the mechanisms involved and the possibilities of …
Intrauterine growth restriction as a potential risk factor for disease onset in adulthood
AA Varvarigou - Journal of Pediatric Endocrinology and Metabolism, 2010 - degruyter.com
Intrauterine growth restriction (IUGR) is a risk factor for cardiovascular disease, type 2
diabetes mellitus, and obesity in adulthood. Several studies on diverse geographic and …
diabetes mellitus, and obesity in adulthood. Several studies on diverse geographic and …
Impact of consuming extra-virgin olive oil or nuts within a Mediterranean diet on DNA methylation in peripheral white blood cells within the PREDIMED-Navarra …
DNA methylation could be reversible and mouldable by environmental factors, such as
dietary exposures. The objective was to analyse whether an intervention with two …
dietary exposures. The objective was to analyse whether an intervention with two …
Prevalence, risk factors and complications associated with type 2 diabetes in migrant South Asians
SD Garduño‐Diaz, S Khokhar - Diabetes/metabolism research …, 2012 - Wiley Online Library
It is estimated that type 2 diabetes (T2D) currently affects about 246 million people
worldwide, with South Asians, especially Indians, having both the largest number of cases …
worldwide, with South Asians, especially Indians, having both the largest number of cases …
Early-life nutritional programming of longevity
AM Vaiserman - Journal of developmental origins of health and …, 2014 - cambridge.org
Available data from both experimental and epidemiological studies suggest that inadequate
diet in early life can permanently change the structure and function of specific organs or …
diet in early life can permanently change the structure and function of specific organs or …
Do environmental pollutants increase obesity risk in humans?
Y Wang, K Hollis‐Hansen, X Ren, Y Qiu… - Obesity …, 2016 - Wiley Online Library
Objectives Obesity has become a global epidemic and threat to public health. A good
understanding of the causes can help attenuate the risk and spread. Environmental …
understanding of the causes can help attenuate the risk and spread. Environmental …
Transgenerational impaired male fertility with an Igf2 epigenetic defect in the rat are induced by the endocrine disruptor p,p′-DDE
Y Song, N Wu, S Wang, M Gao, P Song… - Human …, 2014 - academic.oup.com
Since the 1990s, various studies (Carlsen et al., 1992; Swan et al., 2000; Rolland et al.,
2013) have reported that young males in developed or industrialized countries have …
2013) have reported that young males in developed or industrialized countries have …
Species Differences between mouse and human pparα in modulating the hepatocarcinogenic effects of perinatal exposure to a high-affinity human PPARα agonist in …
JE Foreman, T Koga, O Kosyk, BH Kang… - Toxicological …, 2021 - academic.oup.com
Evidence suggests that species differences exist between rodents and humans in their
biological responses to ligand activation of PPARα. Moreover, neonatal/postnatal rodents …
biological responses to ligand activation of PPARα. Moreover, neonatal/postnatal rodents …