Reviewing the current picture of uremic toxicity reveals its complexity. Focusing on
cardiovascular damage as a model of uremic effects resulting in substantial morbidity and …

The understanding of the nucleotide/P2 receptor system in the regulation of renal
hemodynamics and transport function has grown exponentially over the last 20 yr. This …

The involvement of purinergic signalling in kidney physiology and pathophysiology is rapidly
gaining recognition and this is a comprehensive review of early and recent publications in …

Nucleotides and nucleosides are not only involved in cellular metabolism but also act
extracellularly via P1 and P2 receptors, to elicit a wide variety of physiological and …

The purinergic system is composed of mononucleosides, mononucleoside polyphosphates
and dinucleoside polyphosphates as agonists, as well as the respective purinergic …

Chronic kidney disease (CKD) is a state of chronic, low‐grade inflammation which
contributes to the accelerated progression of chronic inflammatory disturbances of which …

The invention of dialysis has been a phenomenal advance in the treatment of kidney failure.
The introduction of artificial kidneys in clinical care remains one of the most successful …

Peritubular fibroblasts in the kidney are the major erythropoietin-producing cells and also
contribute to renal repair following acute kidney injury (AKI). Although few fibroblasts were …

In this publication, we review the activities of the European Uremic Toxin Work Group
(EUTox) in the field of uremic toxin research. Founded in 1999 under the umbrella of the …

INTRODUCTION—The uremic syndrome can be defined as the deterioration of multiple
biochemical and physiological functions in parallel with progressive kidney dysfunction …