[HTML][HTML] miRNAs as biomarkers in disease: latest findings regarding their role in diagnosis and prognosis
CE Condrat, DC Thompson, MG Barbu, OL Bugnar… - Cells, 2020 - mdpi.com
MicroRNAs (miRNAs) represent a class of small, non-coding RNAs with the main roles of
regulating mRNA through its degradation and adjusting protein levels. In recent years …
regulating mRNA through its degradation and adjusting protein levels. In recent years …
[HTML][HTML] Pathogenic mechanisms associated with different clinical courses of multiple sclerosis
H Lassmann - Frontiers in immunology, 2019 - frontiersin.org
In the majority of patients multiple sclerosis starts with a relapsing remitting course (RRMS),
which may at later times transform into secondary progressive disease (SPMS). In a minority …
which may at later times transform into secondary progressive disease (SPMS). In a minority …
The potential of serum neurofilament as biomarker for multiple sclerosis
Multiple sclerosis is a highly heterogeneous disease, and the detection of neuroaxonal
damage as well as its quantification is a critical step for patients. Blood-based serum …
damage as well as its quantification is a critical step for patients. Blood-based serum …
[HTML][HTML] Exosomal microRNA signatures in multiple sclerosis reflect disease status
Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system (CNS). There is currently no single definitive test for MS. Circulating …
nervous system (CNS). There is currently no single definitive test for MS. Circulating …
[HTML][HTML] Detrimental and protective action of microglial extracellular vesicles on myelin lesions: astrocyte involvement in remyelination failure
M Lombardi, R Parolisi, F Scaroni, E Bonfanti… - Acta …, 2019 - Springer
Microglia are highly plastic immune cells which exist in a continuum of activation states. By
shaping the function of oligodendrocyte precursor cells (OPCs), the brain cells which …
shaping the function of oligodendrocyte precursor cells (OPCs), the brain cells which …
Association between serum neurofilament light chain levels and long-term disease course among patients with multiple sclerosis followed up for 12 years
Importance Blood sample–based biomarkers that are associated with clinically meaningful
outcomes for patients with multiple sclerosis (MS) have not been developed. Objective To …
outcomes for patients with multiple sclerosis (MS) have not been developed. Objective To …
Toward precision phenotyping of multiple sclerosis
The classification of multiple sclerosis (MS) has been established by Lublin in 1996 and
revised in 2013. The revision includes clinically isolated syndrome, relapsing-remitting …
revised in 2013. The revision includes clinically isolated syndrome, relapsing-remitting …
The search for the target antigens of multiple sclerosis, part 1: autoreactive CD4+ T lymphocytes as pathogenic effectors and therapeutic targets
R Hohlfeld, K Dornmair, E Meinl, H Wekerle - The Lancet Neurology, 2016 - thelancet.com
Identification of the target antigens of pathogenic antibodies and T cells is of fundamental
importance for understanding the pathogenesis of multiple sclerosis, and for the …
importance for understanding the pathogenesis of multiple sclerosis, and for the …
Biomarkers in multiple sclerosis
A Paul, M Comabella, R Gandhi - Cold Spring …, 2019 - perspectivesinmedicine.cshlp.org
Multiple sclerosis (MS) is a chronic neurodegenerative autoimmune disease with a complex
clinical course characterized by inflammation, demyelination, and axonal degeneration …
clinical course characterized by inflammation, demyelination, and axonal degeneration …
Neurodegenerative disorders of alzheimer, parkinsonism, amyotrophic lateral sclerosis and multiple sclerosis: an early diagnostic approach for precision treatment
Neurodegenerative diseases (NDs) are characterised by progressive dysfunction of
synapses, neurons, glial cells and their networks. Neurodegenerative diseases can be …
synapses, neurons, glial cells and their networks. Neurodegenerative diseases can be …