Toward explainable artificial intelligence for precision pathology
The rapid development of precision medicine in recent years has started to challenge
diagnostic pathology with respect to its ability to analyze histological images and …
diagnostic pathology with respect to its ability to analyze histological images and …
Adjuvant and neoadjuvant immunotherapies in hepatocellular carcinoma
Liver cancer, specifically hepatocellular carcinoma (HCC), is the sixth most common cancer
and the third leading cause of cancer mortality worldwide. The development of effective …
and the third leading cause of cancer mortality worldwide. The development of effective …
Cooperation between melanoma cell states promotes metastasis through heterotypic cluster formation
Melanomas can have multiple coexisting cell states, including proliferative (PRO) versus
invasive (INV) subpopulations that represent a" go or grow" trade-off; however, how these …
invasive (INV) subpopulations that represent a" go or grow" trade-off; however, how these …
Prognostic biomarkers of cutaneous melanoma
L Ding, A Gosh, DJ Lee, G Emri… - Photodermatology …, 2022 - Wiley Online Library
Background/purpose Melanomas account for only approximately 4% of diagnosed skin
cancers in the United States but are responsible for the majority of deaths caused by skin …
cancers in the United States but are responsible for the majority of deaths caused by skin …
Advancements in melanoma cancer metastasis models
LM Nascentes Melo, S Kumar, V Riess… - Pigment cell & …, 2023 - Wiley Online Library
Metastatic melanoma is a complex and deadly disease. Due to its complexity, the
development of novel therapeutic strategies to inhibit metastatic melanoma remains an …
development of novel therapeutic strategies to inhibit metastatic melanoma remains an …
Identifying the transcriptional drivers of metastasis embedded within localized melanoma
In melanoma, predicting which tumors will ultimately metastasize guides treatment
decisions. Transcriptional signatures of primary tumors have been utilized to predict …
decisions. Transcriptional signatures of primary tumors have been utilized to predict …
Using a clinicopathologic and gene expression (CP-GEP) model to identify stage I–II melanoma patients at risk of disease relapse
EEAP Mulder, I Johansson, DJ Grünhagen, D Tempel… - Cancers, 2022 - mdpi.com
Simple Summary More than 40% of patients initially diagnosed with 'low risk'(stage I–II)
melanoma eventually develop melanoma recurrence or die as a result of melanoma. While …
melanoma eventually develop melanoma recurrence or die as a result of melanoma. While …
Detailed spatial immunophenotyping of primary melanomas reveals immune cell subpopulations associated with patient outcome
GH Attrill, H Lee, AT Tasker, NA Adegoke… - Frontiers in …, 2022 - frontiersin.org
While the tumor immune microenvironment (TIME) of metastatic melanoma has been well
characterized, the primary melanoma TIME is comparatively poorly understood. Additionally …
characterized, the primary melanoma TIME is comparatively poorly understood. Additionally …
Tislelizumab plus cetuximab and irinotecan in refractory microsatellite stable and RAS wild-type metastatic colorectal cancer: a single-arm phase 2 study
X Xu, L Ai, K Hu, L Liang, M Lv, Y Wang, Y Cui… - Nature …, 2024 - nature.com
Immunotherapy confers little to no benefit in the treatment of microsatellite stable (MSS)
metastatic colorectal cancer (mCRC). Mechanistic insights suggested that epidermal growth …
metastatic colorectal cancer (mCRC). Mechanistic insights suggested that epidermal growth …
Two subtypes of cutaneous melanoma with distinct mutational signatures and clinico-genomic characteristics
Background: To decipher mutational signatures and their associations with biological
implications in cutaneous melanomas (CMs), including those with a low ultraviolet (UV) …
implications in cutaneous melanomas (CMs), including those with a low ultraviolet (UV) …