Food is a potent natural reward and food intake is a complex process. Reward and
gratification associated with food consumption leads to dopamine (DA) production, which in …

Obesity markedly increases the odds of developing depression. Depressed mood not only
impairs motivation, quality of life and overall functioning but also increases the risks of …

Leptin, a hormone secreted from adipose tissue, was originally discovered to regulate body
weight. The localization of the leptin receptor in limbic structures suggests a potential role for …

Global levels of obesity are reaching epidemic proportions, leading to a dramatic increase in
incidence of secondary diseases and the significant economic burden associated with their …

Given the array of biological changes induced by stressors, it is not surprising that these
experiences may provoke a variety of illnesses. Among others things, stressors promote …

Currently, the diagnosis of major depressive disorder (MDD) mainly relies on clinical
examination and subjective evaluation of depressive symptoms. There is no non-invasive …

Background Major depressive disorder (MDD) is a heterogeneous mental disorder having a
very diverse course and causing a significant changes in daily life. Though the exact …

Leptin plays a key role in the pathogenesis of obesity and depression via the long form of
leptin receptor (LepRb). An animal model of comorbid obesity and depression induced by …

Osteoporosis is a major public health threat. Multiple studies have reported an association
between depression and low bone mineral density, but a causal link between these two …

Leptin, produced and secreted by white adipose tissue, plays a critical role in regulating
body weight, food intake, and energy metabolism. Recently, several studies have identified …