The cytokine IL-7 and its receptor, IL-7R, are critical for T cell and, in the mouse, B cell
development, as well as differentiation and survival of naive T cells, and generation and …

Cancer vaccines exhibit specificity, effectiveness, and safety as an alternative
immunotherapeutic strategy to struggle against malignant diseases, especially with the rapid …

Aging is associated with impaired hematopoietic and immune function caused in part by
decreased fitness in the hematopoietic stem cell (HSC) population and an increased …

The emergence of immunotherapy for cancer treatment bears considerable clinical promise.
Nevertheless, many patients remain unresponsive, acquire resistance, or suffer dose …

Cancer and autoimmune disease are closely related, and many therapeutic antibodies are
widely used in clinics for the treatment of both diseases. Among them, the anti-CD20 …

T-cell malignancies are associated with frequent relapse and high morbidity, which is partly
due to the lack of effective or targeted treatment options. To broaden the use of CAR-T cells …

Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is a distinct subtype of T
lymphoblastic leukemia (T-ALL) identified in 2009, due to its unique immunophenotypic and …

Chimeric antigen receptor (CAR) T cell therapy, a type of adoptive cell therapy, has been
successfully used when treating lymphoma malignancies, but not nearly as successful in …

Avian has a unique immune system that evolved in response to environmental pressures in
all aspects of innate and adaptive immune responses, including localized and circulating …

Dynamic, coordinated changes in metabolic pathway activity underpin the protective and
inflammatory activity of T cells, through provision of energy and biosynthetic precursors for …