Nitric oxide production in response to flow-dependent shear forces applied on the surface of
endothelial cells is a fundamental mechanism of regulation of vascular tone, peripheral …

The complex regulation of eNOS (endothelial nitric oxide synthase) in cardiovascular
physiology occurs at multiple stages. eNOS mRNA levels are controlled both at the …

▪ Abstract Nitric oxide (NO) is a small, diffusible, lipophilic free radical gas that mediates
significant and diverse signaling functions in nearly every organ system in the body. The …

The regulation of endothelial NO synthase (eNOS) employs multiple different cellular control
mechanisms impinging on level and activity of the enzyme. This review aims at summarizing …

Nitric oxide (NO) production by endothelial cell nitric oxide synthase (eNOS) in sinusoidal
endothelial cells is reduced in the injured liver and leads to intrahepatic portal hypertension …

We examined the influence of individual serine phosphorylation sites in endothelial nitric-
oxide synthase (eNOS) on basal and stimulated NO release, cooperative phosphorylation …

The endothelial isoform of nitric-oxide synthase (eNOS) is regulated by a complex pattern of
post-translational modifications. In these studies, we show that eNOS is dynamically …

We investigated the role of micro RNA s (mi RNA) in endothelial dysfunction in the setting of
cardiometabolic disorders represented by type 2 diabetes mellitus (T2DM). miR‐29 was …

Membranes are of outmost importance to allow for specific signal transduction due to their
ability to localize, amplify, and direct signals. However, due to the double-edged nature of …

Endothelial nitric oxide (NO) is a significant signaling molecule that regulates cerebral blood
flow (CBF), playing a pivotal role in the prevention and treatment of cerebrovascular …