Predicting weight gain in patients treated with clozapine: the role of sex, body mass index, and smoking
Objectives Weight gain on clozapine is highly variable and poorly predictable. Its
mechanisms are not well understood. This study explores the factors that predict weight gain …
mechanisms are not well understood. This study explores the factors that predict weight gain …
Development of multivariable models to predict change in Body Mass Index within a clinical trial population of psychotic individuals
RNS Harrison, F Gaughran, RM Murray, SH Lee… - Scientific Reports, 2017 - nature.com
Many antipsychotics promote weight gain, which can lead to non-compliance and relapse of
psychosis. By developing models that accurately identify individuals at greater risk of weight …
psychosis. By developing models that accurately identify individuals at greater risk of weight …
Resistin as an inflammatory marker in patients with schizophrenia treated with clozapine
JP Klemettilä, O Kampman, N Seppälä… - Nordic Journal of …, 2017 - Taylor & Francis
Background: Schizophrenia is associated with excess cardiovascular comorbidity and
mortality related to lifestyle factors, such as lack of physical activity, poor diet, and smoking …
mortality related to lifestyle factors, such as lack of physical activity, poor diet, and smoking …
Pharmacometric modeling of drug adverse effects: an application of mixture models in schizophrenia spectrum disorder patients treated with clozapine
Clozapine has superior efficacy to other antipsychotics yet is underutilized due to its adverse
effects, such as neutropenia, weight gain, and tachycardia. The current investigation aimed …
effects, such as neutropenia, weight gain, and tachycardia. The current investigation aimed …