The immunomodulatory functions of mesenchymal stromal/stem cells mediated via paracrine activity

Y Zhou, Y Yamamoto, Z Xiao, T Ochiya - Journal of clinical medicine, 2019 - mdpi.com
Mesenchymal stromal/stem cells (MSCs) exist in almost all tissues, possessing the potential
to differentiate into specialized cell types and exert immunomodulatory functions. Thus, they …

Paracrine mechanisms of mesenchymal stem cell-based therapy: current status and perspectives

X Liang, Y Ding, Y Zhang, HF Tse… - Cell …, 2014 - journals.sagepub.com
Mesenchymal stem cells (MSCs) are one of a few stem cell types to be applied in clinical
practice as therapeutic agents for immunomodulation and ischemic tissue repair. In addition …

Trophic effects of mesenchymal stem cells in tissue regeneration

Y Fu, L Karbaat, L Wu, J Leijten, SK Both… - … Engineering Part B …, 2017 - liebertpub.com
Mesenchymal stem cells (MSCs) are considered to hold great therapeutic value for cell-
based therapy and for tissue regeneration in particular. Recent evidence indicates that the …

Homing of endogenous stem/progenitor cells for in situ tissue regeneration: promises, strategies, and translational perspectives

FM Chen, LA Wu, M Zhang, R Zhang, HH Sun - Biomaterials, 2011 - Elsevier
Stem cell-based therapy has been one of the best documented approaches in regenerative
medicine, promising cures for a multitude of diseases and disorders. However, the ex vivo …

Therapeutic applications of mesenchymal stromal cells: paracrine effects and potential improvements

J Doorn, G Moll, K Le Blanc… - … Engineering Part B …, 2012 - liebertpub.com
Among the various types of cell-to-cell signaling, paracrine signaling comprises those
signals that are transmitted over short distances between different cell types. In the human …

Adipose tissue‐derived mesenchymal stem cells improve revascularization outcomes to restore renal function in swine atherosclerotic renal artery stenosis

A Eirin, XY Zhu, JD Krier, H Tang, KL Jordan… - Stem …, 2012 - academic.oup.com
Reno‐protective strategies are needed to improve renal outcomes in patients with
atherosclerotic renal artery stenosis (ARAS). Adipose tissue‐derived mesenchymal stem …

Urinary extracellular vesicles and the kidney: biomarkers and beyond

M Salih, R Zietse, EJ Hoorn - American Journal of …, 2014 - journals.physiology.org
Extracellular vesicles have been isolated in various body fluids, including urine. The cargo
of urinary extracellular vesicles (uEVs) is composed of proteins and nucleic acids reflecting …

Safety and efficacy of intravenous infusion of allogeneic cryopreserved mesenchymal stem cells for treatment of chronic kidney disease in cats: results of three …

JM Quimby, TL Webb, LM Habenicht… - Stem cell research & …, 2013 - Springer
Introduction Administration of mesenchymal stem cells (MSCs) has been shown to improve
renal function in rodent models of chronic kidney disease (CKD), in part by reducing …

Extracellular membrane vesicles from umbilical cord blood-derived MSC protect against ischemic acute kidney injury, a feature that is lost after inflammatory …

L Kilpinen, U Impola, L Sankkila, I Ritamo… - Journal of …, 2013 - Taylor & Francis
Background Mesenchymal stromal cells (MSC) are shown to have a great therapeutic
potential in many immunological disorders. Currently the therapeutic effect of MSCs is …

Bone marrow stem cell derived paracrine factors for regenerative medicine: current perspectives and therapeutic potential

TJ Burdon, A Paul, N Noiseux, S Prakash… - Bone marrow …, 2011 - Wiley Online Library
During the past several years, there has been intense research in the field of bone marrow‐
derived stem cell (BMSC) therapy to facilitate its translation into clinical setting. Although a …