[HTML][HTML] Redox regulation of FoxO transcription factors
LO Klotz, C Sánchez-Ramos, I Prieto-Arroyo… - Redox biology, 2015 - Elsevier
Transcription factors of the forkhead box, class O (FoxO) family are important regulators of
the cellular stress response and promote the cellular antioxidant defense. On one hand …
the cellular stress response and promote the cellular antioxidant defense. On one hand …
[HTML][HTML] RNA binding protein regulation and cross-talk in the control of AU-rich mRNA fate
SM García-Mauriño, F Rivero-Rodríguez… - Frontiers in molecular …, 2017 - frontiersin.org
mRNA metabolism is tightly orchestrated by highly-regulated RNA Binding Proteins (RBPs)
that determine mRNA fate, thereby influencing multiple cellular functions across biological …
that determine mRNA fate, thereby influencing multiple cellular functions across biological …
Cystathionine γ lyase sulfhydrates the RNA binding protein human antigen R to preserve endothelial cell function and delay atherogenesis
SI Bibli, J Hu, F Sigala, I Wittig, J Heidler, S Zukunft… - Circulation, 2019 - Am Heart Assoc
Background: Hydrogen sulfide (H2S), generated by cystathionine γ lyase (CSE), is an
important endogenous regulator of vascular function. The aim of the present study was to …
important endogenous regulator of vascular function. The aim of the present study was to …
Redox signalling directly regulates TDP‐43 via cysteine oxidation and disulphide cross‐linking
TDP‐43 is the major disease protein in ubiquitin‐positive inclusions of amyotrophic lateral
sclerosis and frontotemporal lobar degeneration (FTLD) characterized by TDP‐43 pathology …
sclerosis and frontotemporal lobar degeneration (FTLD) characterized by TDP‐43 pathology …
Posttranscriptional upregulation of IDH1 by HuR establishes a powerful survival phenotype in pancreatic cancer cells
Cancer aggressiveness may result from the selective pressure of a harsh nutrient-deprived
microenvironment. Here we illustrate how such conditions promote chemotherapy …
microenvironment. Here we illustrate how such conditions promote chemotherapy …
The structure of the ARE-binding domains of Hu antigen R (HuR) undergoes conformational changes during RNA binding
Human RNA-binding protein (HuR), a ubiquitously expressed member of the Hu protein
family, plays an important role in mRNA degradation and has been implicated as a key post …
family, plays an important role in mRNA degradation and has been implicated as a key post …
Regulation of HuR structure and function by dihydrotanshinone-I
P Lal, L Cerofolini, VG D'Agostino, C Zucal… - Nucleic acids …, 2017 - academic.oup.com
The Human antigen R protein (HuR) is an RNA-binding protein that recognizes U/AU-rich
elements in diverse RNAs through two RNA-recognition motifs, RRM1 and RRM2, and post …
elements in diverse RNAs through two RNA-recognition motifs, RRM1 and RRM2, and post …
HuR-targeted agents: an insight into medicinal chemistry, biophysical, computational studies and pharmacological effects on cancer models
G Assoni, V La Pietra, R Digilio, C Ciani… - Advanced Drug Delivery …, 2022 - Elsevier
Abstract The Human antigen R (HuR) protein is an RNA-binding protein, ubiquitously
expressed in human tissues, that orchestrates target RNA maturation and processing both in …
expressed in human tissues, that orchestrates target RNA maturation and processing both in …
Properties of the regulatory RNA-binding protein HuR and its role in controlling miRNA repression
NC Meisner, W Filipowicz - Regulation of microRNAs, 2010 - Springer
Gene expression in eukaryotes is subject to extensive regulation at posttranscriptional
levels. One of the most important sites of control involves mRNA 3′ untranslated regions …
levels. One of the most important sites of control involves mRNA 3′ untranslated regions …
The RNA binding protein HuR: a promising drug target for anticancer therapy
M Wu, CWS Tong, W Yan, KKW To… - Current cancer drug …, 2019 - ingentaconnect.com
The stability of mRNA is one of the key factors governing the regulation of eukaryotic gene
expression and function. Human antigen R (HuR) is an RNA-binding protein that regulates …
expression and function. Human antigen R (HuR) is an RNA-binding protein that regulates …