[HTML][HTML] Redox regulation of FoxO transcription factors

LO Klotz, C Sánchez-Ramos, I Prieto-Arroyo… - Redox biology, 2015 - Elsevier
Transcription factors of the forkhead box, class O (FoxO) family are important regulators of
the cellular stress response and promote the cellular antioxidant defense. On one hand …

[HTML][HTML] RNA binding protein regulation and cross-talk in the control of AU-rich mRNA fate

SM García-Mauriño, F Rivero-Rodríguez… - Frontiers in molecular …, 2017 - frontiersin.org
mRNA metabolism is tightly orchestrated by highly-regulated RNA Binding Proteins (RBPs)
that determine mRNA fate, thereby influencing multiple cellular functions across biological …

Cystathionine γ lyase sulfhydrates the RNA binding protein human antigen R to preserve endothelial cell function and delay atherogenesis

SI Bibli, J Hu, F Sigala, I Wittig, J Heidler, S Zukunft… - Circulation, 2019 - Am Heart Assoc
Background: Hydrogen sulfide (H2S), generated by cystathionine γ lyase (CSE), is an
important endogenous regulator of vascular function. The aim of the present study was to …

Redox signalling directly regulates TDP‐43 via cysteine oxidation and disulphide cross‐linking

TJ Cohen, AW Hwang, T Unger, JQ Trojanowski… - The EMBO …, 2012 - embopress.org
TDP‐43 is the major disease protein in ubiquitin‐positive inclusions of amyotrophic lateral
sclerosis and frontotemporal lobar degeneration (FTLD) characterized by TDP‐43 pathology …

Posttranscriptional upregulation of IDH1 by HuR establishes a powerful survival phenotype in pancreatic cancer cells

M Zarei, S Lal, SJ Parker, A Nevler, A Vaziri-Gohar… - Cancer research, 2017 - AACR
Cancer aggressiveness may result from the selective pressure of a harsh nutrient-deprived
microenvironment. Here we illustrate how such conditions promote chemotherapy …

The structure of the ARE-binding domains of Hu antigen R (HuR) undergoes conformational changes during RNA binding

H Wang, F Zeng, Q Liu, H Liu, Z Liu, L Niu… - … Section D: Biological …, 2013 - scripts.iucr.org
Human RNA-binding protein (HuR), a ubiquitously expressed member of the Hu protein
family, plays an important role in mRNA degradation and has been implicated as a key post …

Regulation of HuR structure and function by dihydrotanshinone-I

P Lal, L Cerofolini, VG D'Agostino, C Zucal… - Nucleic acids …, 2017 - academic.oup.com
The Human antigen R protein (HuR) is an RNA-binding protein that recognizes U/AU-rich
elements in diverse RNAs through two RNA-recognition motifs, RRM1 and RRM2, and post …

HuR-targeted agents: an insight into medicinal chemistry, biophysical, computational studies and pharmacological effects on cancer models

G Assoni, V La Pietra, R Digilio, C Ciani… - Advanced Drug Delivery …, 2022 - Elsevier
Abstract The Human antigen R (HuR) protein is an RNA-binding protein, ubiquitously
expressed in human tissues, that orchestrates target RNA maturation and processing both in …

Properties of the regulatory RNA-binding protein HuR and its role in controlling miRNA repression

NC Meisner, W Filipowicz - Regulation of microRNAs, 2010 - Springer
Gene expression in eukaryotes is subject to extensive regulation at posttranscriptional
levels. One of the most important sites of control involves mRNA 3′ untranslated regions …

The RNA binding protein HuR: a promising drug target for anticancer therapy

M Wu, CWS Tong, W Yan, KKW To… - Current cancer drug …, 2019 - ingentaconnect.com
The stability of mRNA is one of the key factors governing the regulation of eukaryotic gene
expression and function. Human antigen R (HuR) is an RNA-binding protein that regulates …