Developments with multi-target drugs for Alzheimer's disease: An overview of the current discovery approaches

JF González, AR Alcántara, AL Doadrio… - Expert opinion on …, 2019 - Taylor & Francis
Introduction: Alzheimer's disease (AD), the most common type of dementia among older
adults, is a chronic neurodegenerative pathology that causes a progressive loss of cognitive …

Dissecting the relationship between neuropsychiatric and neurodegenerative disorders

R Gupta, D Advani, D Yadav, RK Ambasta… - Molecular …, 2023 - Springer
Neurodegenerative diseases (NDDs) and neuropsychiatric disorders (NPDs) are two
common causes of death in elderly people, which includes progressive neuronal cell death …

In situ fibrillizing amyloid-beta 1-42 induces neurite degeneration and apoptosis of differentiated SH-SY5Y cells

J Krishtal, O Bragina, K Metsla, P Palumaa, V Tõugu - PloS one, 2017 - journals.plos.org
The progression of Alzheimer's disease is causatively linked to the accumulation of amyloid-
β aggregates in the brain, however, it is not clear how the amyloid aggregates initiate the …

Understanding how physical exercise improves Alzheimer's disease: cholinergic and monoaminergic systems

B Zong, F Yu, X Zhang, W Zhao, P Sun… - Frontiers in Aging …, 2022 - frontiersin.org
Alzheimer's disease (AD) is an age-related neurodegenerative disorder, characterized by
the accumulation of proteinaceous aggregates and neurofibrillary lesions composed of β …

5-HIAA induces neprilysin to ameliorate pathophysiology and symptoms in a mouse model for Alzheimer's disease

C Klein, G Roussel, S Brun, C Rusu… - Acta Neuropathologica …, 2018 - Springer
Serotoninergic activation which decreases brain Aβ peptides is considered beneficial in
mouse models for Alzheimer's disease (AD), but the mechanisms involved remain unclear …

Identification of Multi-Target Anti-AD Chemical Constituents From Traditional Chinese Medicine Formulae by Integrating Virtual Screening and In Vitro Validation

B Zhang, J Zhao, Z Wang, P Guo, A Liu… - Frontiers in …, 2021 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disease that seriously threatens the health
of the elderly. At present, no drugs have been proven to cure or delay the progression of the …

Trait anxiety, a personality risk factor associated with Alzheimer's Disease

S Li, C Wang, W Wang, J Tan - Progress in Neuro-Psychopharmacology …, 2021 - Elsevier
Alzheimer's disease (AD) is the most common neurodegenerative disease in elderly
population and the leading cause of dementia worldwide. While senile plaques and …

Novel anilide and benzylamide derivatives of arylpiperazinylalkanoic acids as 5-HT1A/5-HT7 receptor antagonists and phosphodiesterase 4/7 inhibitors with …

A Jankowska, G Satała, M Kołaczkowski… - European Journal of …, 2020 - Elsevier
A library of novel anilide and benzylamide derivatives of ω-(4-(2-methoxyphenyl) piperazin-
1-yl) alkanoic acids as combined 5-HT 1A/5-HT 7 receptor ligands and phosphodiesterase …

Rhodamine-based metal chelator: a potent inhibitor of metal-catalyzed amyloid toxicity

K Pradhan, G Das, C Kar, N Mukherjee, J Khan… - ACS …, 2020 - ACS Publications
Alzheimer's disease (AD) exhibits a multitude of syndromes which add up to its complex
nature. In AD, amyloid plaques are deposited along with abnormal accumulation of …

Interactions of selective serotonin reuptake inhibitors with β-amyloid

G Tin, T Mohamed, A Shakeri, AT Pham… - ACS chemical …, 2018 - ACS Publications
Treating Alzheimer's disease (AD) is a major challenge at the moment with no new drugs
available to cure this devastating neurodegenerative disorder. In this regard, drug …