Technical challenges of studying early human development
PJ Rugg-Gunn, N Moris, PPL Tam - Development, 2023 - journals.biologists.com
Recent years have seen exciting progress across human embryo research, including new
methods for culturing embryos, transcriptional profiling of embryogenesis and gastrulation …
methods for culturing embryos, transcriptional profiling of embryogenesis and gastrulation …
[HTML][HTML] Spatial transcriptomics in development and disease
The proper functioning of diverse biological systems depends on the spatial organization of
their cells, a critical factor for biological processes like shaping intricate tissue functions and …
their cells, a critical factor for biological processes like shaping intricate tissue functions and …
Integrating spatial transcriptomics data across different conditions, technologies and developmental stages
With the rapid generation of spatial transcriptomics (ST) data, integrative analysis of multiple
ST datasets from different conditions, technologies and developmental stages is becoming …
ST datasets from different conditions, technologies and developmental stages is becoming …
A patterned human neural tube model using microfluidic gradients
The human nervous system is a highly complex but organized organ. The foundation of its
complexity and organization is laid down during regional patterning of the neural tube, the …
complexity and organization is laid down during regional patterning of the neural tube, the …
Navigating the landscapes of spatial transcriptomics: How computational methods guide the way
R Li, X Chen, X Yang - Wiley Interdisciplinary Reviews: RNA, 2024 - Wiley Online Library
Spatially resolved transcriptomics has been dramatically transforming biological and
medical research in various fields. It enables transcriptome profiling at single‐cell, multi …
medical research in various fields. It enables transcriptome profiling at single‐cell, multi …
Human pluripotent stem cell-derived inner ear organoids recapitulate otic development in vitro
D Doda, S Alonso Jimenez, H Rehrauer… - …, 2023 - journals.biologists.com
Our molecular understanding of the early stages of human inner ear development has been
limited by the difficulty in accessing fetal samples at early gestational stages. As an …
limited by the difficulty in accessing fetal samples at early gestational stages. As an …
How developmental cell atlases inform stem cell embryo models
How developmental cell atlases inform stem cell embryo models | Nature Methods Skip to main
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content Thank you for visiting nature.com. You are using a browser version with limited support …
Mapping Cell Atlases at the Single‐Cell Level
Recent advancements in single‐cell technologies have led to rapid developments in the
construction of cell atlases. These atlases have the potential to provide detailed information …
construction of cell atlases. These atlases have the potential to provide detailed information …
[HTML][HTML] In vitro and in vivo models define a molecular signature reference for human embryonic notochordal cells
Understanding the emergence of human notochordal cells (NC) is essential for the
development of regenerative approaches. We present a comprehensive investigation into …
development of regenerative approaches. We present a comprehensive investigation into …
Decoding the universal human chromatin landscape through teratoma-based profiling
BL Kidder - Nucleic Acids Research, 2024 - academic.oup.com
Teratoma formation is key for evaluating differentiation of human pluripotent stem cells into
embryonic germ layers and serves as a model for understanding stem cell differentiation …
embryonic germ layers and serves as a model for understanding stem cell differentiation …