Technical challenges of studying early human development

PJ Rugg-Gunn, N Moris, PPL Tam - Development, 2023 - journals.biologists.com
Recent years have seen exciting progress across human embryo research, including new
methods for culturing embryos, transcriptional profiling of embryogenesis and gastrulation …

[HTML][HTML] Spatial transcriptomics in development and disease

R Zhou, G Yang, Y Zhang, Y Wang - Molecular Biomedicine, 2023 - Springer
The proper functioning of diverse biological systems depends on the spatial organization of
their cells, a critical factor for biological processes like shaping intricate tissue functions and …

Integrating spatial transcriptomics data across different conditions, technologies and developmental stages

X Zhou, K Dong, S Zhang - Nature Computational Science, 2023 - nature.com
With the rapid generation of spatial transcriptomics (ST) data, integrative analysis of multiple
ST datasets from different conditions, technologies and developmental stages is becoming …

A patterned human neural tube model using microfluidic gradients

X Xue, YS Kim, AI Ponce-Arias, R O'Laughlin, RZ Yan… - Nature, 2024 - nature.com
The human nervous system is a highly complex but organized organ. The foundation of its
complexity and organization is laid down during regional patterning of the neural tube, the …

Navigating the landscapes of spatial transcriptomics: How computational methods guide the way

R Li, X Chen, X Yang - Wiley Interdisciplinary Reviews: RNA, 2024 - Wiley Online Library
Spatially resolved transcriptomics has been dramatically transforming biological and
medical research in various fields. It enables transcriptome profiling at single‐cell, multi …

Human pluripotent stem cell-derived inner ear organoids recapitulate otic development in vitro

D Doda, S Alonso Jimenez, H Rehrauer… - …, 2023 - journals.biologists.com
Our molecular understanding of the early stages of human inner ear development has been
limited by the difficulty in accessing fetal samples at early gestational stages. As an …

How developmental cell atlases inform stem cell embryo models

M Haniffa, A Maartens, SA Teichmann - Nature Methods, 2023 - nature.com
How developmental cell atlases inform stem cell embryo models | Nature Methods Skip to main
content Thank you for visiting nature.com. You are using a browser version with limited support …

Mapping Cell Atlases at the Single‐Cell Level

F Ye, J Wang, J Li, Y Mei, G Guo - Advanced Science, 2024 - Wiley Online Library
Recent advancements in single‐cell technologies have led to rapid developments in the
construction of cell atlases. These atlases have the potential to provide detailed information …

[HTML][HTML] In vitro and in vivo models define a molecular signature reference for human embryonic notochordal cells

J Warin, N Vedrenne, V Tam, M Zhu, D Yin, X Lin… - Iscience, 2024 - cell.com
Understanding the emergence of human notochordal cells (NC) is essential for the
development of regenerative approaches. We present a comprehensive investigation into …

Decoding the universal human chromatin landscape through teratoma-based profiling

BL Kidder - Nucleic Acids Research, 2024 - academic.oup.com
Teratoma formation is key for evaluating differentiation of human pluripotent stem cells into
embryonic germ layers and serves as a model for understanding stem cell differentiation …