Our incomplete understanding of the causes and pathways involved in the onset and
progression of multiple sclerosis (MS) limits our ability to effectively treat this complex …

Epidemiology and Pathophysiology of Multiple Sclerosis : CONTINUUM: Lifelong Learning in
Neurology Account Register Activate Subscription Help Subscribe American Academy of …

INTRODUCTION Myeloid cells are highly heterogeneous, with distinct ontogenies and
immune functions. The diverse role of myeloid populations, including monocytes …

N6-methyladenosine (m6A) modification is dynamically regulated by “writer” and “eraser”
enzymes. m6A “writers” have been shown to ensure the homeostasis of CD4+ T cells, but …

The origin and function of CD20+ T cells are poorly understood. Here, we characterized
CD20+ T cells in mice and humans and investigated how they are affected by anti-CD20 …

Ophthalmic inflammatory diseases, including conjunctivitis, keratitis, uveitis, scleritis, and
related conditions, pose considerable challenges to effective management and treatment …

Microglia, the parenchymal brain macrophages of the central nervous system, have
emerged as critical players in brain development and homeostasis. The immune functions of …

Background Intermittent fasting or calorie restriction (CR) diets provide anti-inflammatory
and neuroprotective advantages in models of multiple sclerosis (MS); data in humans are …

Glial cells and central nervous system (CNS)-infiltrating leukocytes contribute to multiple
sclerosis (MS). However, the networks that govern crosstalk among these ontologically …

Background Over the past few years, mesenchymal stromal cells (MSCs) have attracted a
great deal of scientific attention owing to their promising results in the treatment of incurable …