[HTML][HTML] Designing spatial and temporal control of vaccine responses

GA Roth, VCTM Picece, BS Ou, W Luo… - Nature Reviews …, 2022 - nature.com
Vaccines are the key technology to combat existing and emerging infectious diseases.
However, increasing the potency, quality and durability of the vaccine response remains a …

[HTML][HTML] High-resolution two-photon polymerization: The most versatile technique for the fabrication of microneedle arrays

Z Faraji Rad, PD Prewett, GJ Davies - Microsystems & nanoengineering, 2021 - nature.com
Microneedle patches have received much interest in the last two decades as drug/vaccine
delivery or fluid sampling systems for diagnostic and monitoring purposes. Microneedles are …

Microneedle aptamer-based sensors for continuous, real-time therapeutic drug monitoring

Y Wu, F Tehrani, H Teymourian, J Mack… - Analytical …, 2022 - ACS Publications
The ability to continuously monitor the concentration of specific molecules in the body is a
long-sought goal of biomedical research. For this purpose, interstitial fluid (ISF) was …

Microneedles for painless transdermal immunotherapeutic applications

H Amani, MA Shahbazi, C D'Amico, F Fontana… - Journal of Controlled …, 2021 - Elsevier
Immunotherapy has recently garnered plenty of attention to improve the clinical outcomes in
the treatment of various diseases. However, owing to the dynamic nature of the immune …

Transdermal microneedles for the programmable burst release of multiple vaccine payloads

KTM Tran, TD Gavitt, NJ Farrell, EJ Curry… - Nature Biomedical …, 2021 - nature.com
Repeated bolus injections are associated with higher costs and poor compliance and can
hinder the implementation of global immunization campaigns. Here, we report the …

[HTML][HTML] Transdermal drug delivery: Innovative pharmaceutical developments based on disruption of the barrier properties of the stratum corneum

A Zaid Alkilani, MTC McCrudden, RF Donnelly - Pharmaceutics, 2015 - mdpi.com
The skin offers an accessible and convenient site for the administration of medications. To
this end, the field of transdermal drug delivery, aimed at developing safe and efficacious …

[HTML][HTML] Microneedle-based delivery: An overview of current applications and trends

AJ Guillot, AS Cordeiro, RF Donnelly, MC Montesinos… - Pharmaceutics, 2020 - mdpi.com
Pharmaceutics | Free Full-Text | Microneedle-Based Delivery: An Overview of Current
Applications and Trends Next Article in Journal Injectable Lipid-Based Depot Formulations …

[HTML][HTML] Advanced nanocarrier-and microneedle-based transdermal drug delivery strategies for skin diseases treatment

F Qu, R Geng, Y Liu, J Zhu - Theranostics, 2022 - ncbi.nlm.nih.gov
Skin diseases are the fourth leading cause of nonfatal and chronic skin diseases, acting as a
global burden and affecting the world economy. Skin diseases severely impact the patients' …

A review of recent advances in microneedle technology for transdermal drug delivery

R Nagarkar, M Singh, HX Nguyen… - Journal of Drug Delivery …, 2020 - Elsevier
Transdermal devices are used to deliver drugs through the skin. However, limitations such
as molecular weight and hydrophilicity of the molecules prevent its wider use. Microneedle …

[HTML][HTML] Sustained delivery approaches to improving adaptive immune responses

BS Ou, OM Saouaf, J Baillet, EA Appel - Advanced Drug Delivery Reviews, 2022 - Elsevier
The immune system is one of the most important, complex biological networks regulating
and protecting human health. Its precise modulation can prevent deadly infections and fight …